The Cold Chain. Definition Vaccines are sensitive to heat and freezing and must be kept at the correct temperature from the time they are manufactured.

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Presentation transcript:

The Cold Chain

Definition Vaccines are sensitive to heat and freezing and must be kept at the correct temperature from the time they are manufactured until they are used The system used for keeping and distributing vaccines in good condition is called the cold chain the equipment and people that keep vaccines cold during their journey are together must never be broken.

Maintenance of the cold chain requires vaccine and diluent to be: collected from an airport as soon as it arrives transported at the correct temperature from the airport and from one store to another stored at the correct temperature in central, regional and district stores and in health centres transported at the correct temperature to outreach sites kept cold during immunization sessions

Illustrates the cold chain

cold-chain equipment Different levels of the health care system need different equipment for transporting and storing vaccine and diluent at the correct temperature. Central and regional stores need cold rooms, freezers, refrigerators and cold boxes (for transportation). District stores need freezers, refrigerators and cold boxes. Health centres need refrigerators, cold boxes and vaccine carriers.

Cold chain equipment 1. Refrigerators : - freezer below 0° C. - main section +2° C and +8° C 2. Cold boxes : an insulated container that can be lined with frozen ice packs to keep vaccines and diluents cold 3. Vaccine carriers : Like cold boxes

Refrigerators Refrigerators have different capacities for storing vaccine and for freezing and storing ice packs. Vaccine refrigerators have two sections: A main section for storing vaccines and diluents, in which the temperature should be kept between +2° C and +8° C. Thermostats in this section are used to adjust the temperature. A freezer for freezing ice packs,this section should be kept below 0° C. Should be able to hold: frozen ice packs or bottles of water in the bottom of the refrigerator to keep it cool if the power fails; and nothing in half the total space available to allow air to circulate around the vaccines and diluent so as to keep them cool.

Vaccine carriers Like cold boxes, vaccine carriers are insulated containers that can be lined with frozen ice packs to keep vaccines and diluents cold. are smaller than cold boxes and easier to carry if you are walking do not stay cold as long – only for hours are used to transport vaccine and diluent to outreach sites and for temporary storage during health centre immunization sessions

4. Foam pads A foam pad is a piece of soft foam that fist on top of the ice-pack in a vaccines carrier 5. Ice-packs Ice packs are flat, square plastic bottles that are filled with water and frozen.

A foam pad is a piece of soft foam that fits on top of the ice packs in a vaccine carrier. When the carrier lid is open the foam pad keeps the vaccines underneath in a cool state. It also holds and protects vaccine vials during immunization sessions. Cups with ice and ice packs are no longer recommended for holding vaccine and diluent during sessions Do not put opened vials in the holes that are made in some ice packs. Use a foam pad

Ice packs Ice packs are flat, square plastic bottles that can be filled with water and frozen. The required number in a particular cold box or vaccine carrier varies available in two sizes: 0.6 litre for cold boxes; 0.4 litre for vaccine carriers should have two sets of ice packs, one being frozen while the other is in use.

Monitoring the temperature in vaccine storage Thermometers Vaccine cold-chain monitors Freeze watch indicators STOP watch refrigerator monitors Vaccine vial monitors (VVM) Shake test

Thermometers Dial and liquid crystal thermometers : to monitor the temperature of refrigerators, cold boxes and vaccine carriers should not be used alone in refrigerators because they do not operate at temperatures below freezing Waterproof liquid crystal thermometer Dial thermometer

a card which changes color when vaccine is exposed to temperatures that are too high to estimate the length of time that vaccine has been exposed to high temperature. Vaccine cold-chain monitors card

Freeze indicators Freeze Watch consists of a small vial of red liquid attached to a white card and covered in plastic The vial breaks if the temperature where the indicator is located drops below 0° C for more than one hour, and the vaccine must then be destroyed. Freeze indicators

STOP watch refrigerator monitors combines two indicators : One indicator tells you whether vaccine has been exposed to temperatures above +10° C The other indicates whether the temperature has dropped below –4° C. used in vaccine refrigerators

Vaccine vial monitors a label on a vaccine vial that changes color when exposed to heat over a period of time check the VVM before they open a vial to see whether the vaccine has been damaged by heat. Manufacturers attach VVMs to vial of most vaccine. The VVM is printed on the vial label of cap Use only vial with inner squares that are lighter in color than the outside circle.

The shake test to determine whether vaccine has been frozen DPT, Hepatitis B and Tetanus Toxoid vaccines can be damaged by freezing You can find out whether this has occurred by using the shake test Take two DPT vials, one that you think might have been frozen and another from the same manufacturer which you KNOW has never been frozen. Shake both vials. Look at the vaccine inside the two vials (see figure). Let the sediment settle for minutes. Again look at the vaccine inside the two vials (see figure).

The shake test

Vaccines carrier and foam pad Cold box Iced Pack

Heat sensitivity RangeVaccine Most sensitive OPV Measles, MR, MMR DTP, DTP-HepB, DTP-HepB+Hib, YF BCG Hib, DT Least sensitive Td, TT, HepB

Freeze sensitivity RangeVaccine Most sensitive HepB Hib liquid DTP, DTP-HepB, DTP- HepB+Hib, YF DT Td Least sensitive TT, Hib lyophilized

Maintaining the correct temperature in cold boxes and vaccine carriers Keep the lid tightly on the vaccine carrier in transit. During immunization sessions, keep opened vials on the foam pad of your vaccine carrier. The foam pad keeps vaccines inside the carrier cool while providing a place to hold and protect vaccine vials in use. Do not put vials back inside the carrier after each use: if you keep lifting up the foam pad the inside of the carrier will become warm. Keep cold boxes and vaccine carriers in the shade. Do not leave a cold box or vaccine carrier in a vehicle that is standing in the sun. Take it out of the vehicle and put it in the shade.

Student will practice How to load cold-chain equipment How to monitor and adjust the temperature How to maintain cold-chain equipment Shake test to determine whether vaccine has been frozen

Load Vaccine refrigerators Freeze and store frozen ice packs in the freezer. Put vaccines and diluents on the top and middle shelves of the main section: OPV and measles vaccine on the top shelf BCG, DPT, TT, hepatitis B and yellow fever vaccines on the middle shelves diluents next to the vaccines with which they were supplied. Arrange the boxes of vaccine in stacks between which the air can move.

Load Vaccine refrigerators Keep unopened vials that have been taken out of the refrigerator in a special box in the main section labelled “returned”. Use these vials first in the next session. You may keep opened vials of OPV, DPT, TT and Hepatitis B vaccines for use in the next session if: the expiry date has not passed; the vaccines have been stored at a temperature between 0° C and 8° C; they have not been taken out of the health centre for outreach activities, national immunization days, or other purposes. (When opened vials have been taken out of a health centre they must be discarded at the end of the day.)

Load Vaccine refrigerators Discard opened vials of BCG, measles vaccine and yellow fever vaccine. Keep plastic bottles or ice packs filled with water on the bottom shelf. They help to keep the temperature constant. DO NOT : put vaccines on the door shelves: the temperature is not low enough. keep expired vaccines in the refrigerator. Throw them away or return them to the district store keep any food, drink or drugs in a vaccine refrigerator

Load Cold boxes and vaccine carriers Quickly take all the frozen ice packs as you need from the freezer and close the door. Put ice packs against each of the four sides of the cold box or vaccine carrier. Quickly take all the vaccines and diluent you need from the main section of the refrigerator and close the door Put the vaccines and diluent in the middle of the cold box or carrier. Vials may be kept in their boxes or packed without them, depending on how many vials you need.

Load Cold boxes and vaccine carriers Do not let DPT, TT or hepatitis B vaccine vials touch the ice packs. Put newspaper or cardboard around them to protect them from freezing Put a thermometer on top of the vaccines unless vaccine vial monitors are attached to the vials. ice packs on top of the vaccines. For vaccine carriers, place a foam pad on top of the ice packs. Close the carrier lid tightly.