Advances in Stem Cell Therapy Karim Nayernia Professor of Human Genetics & Stem Cell Biology.

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Presentation transcript:

Advances in Stem Cell Therapy Karim Nayernia Professor of Human Genetics & Stem Cell Biology

Stem cells: Balance between proliferation and differentiation

Stem cells: Developmental origin

Proliferation versus Differentiation

Therapeutical purposes: cell-based therapy, gene therapy new approaches for the treatment of cardiovascular, neurodegenerative and musculoskeletal diseases, as well as diabetes and cancer Understanding about the early development Understanding about pathophysiology of diseases Cell-based phenotypic and pathway-specific screens of chemicals Stem Cell Application

Sources of Stem Cells (I)

Sources of Stem Cells (II): iPS Cells

Adult vs. Embryonic Stem cells

How to make an organ, tissue engineering Limited cell availability Immunological rejection Control of stem cell fate, directed differentiation Policy issues Ethical issues Social issues Legal issues Problems to be overcome

Stem Cell Therapy Stem Cell isolation and culture (AD-MSC) Tissue Engineering Animal Models

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