Quantifying Waddington landscapes and paths of non- adiabatic cell fate decisions for differentiation, reprogramming and transdifferentiation by Chunhe Li, and Jin Wang Interface Volume 10(89): December 6, 2013 ©2013 by The Royal Society

The wiring diagram for the stem cell developmental network including nine core gene nodes and their interactions (arrows represent activation and short bars represent repression) (a). Chunhe Li, and Jin Wang J. R. Soc. Interface 2013;10: ©2013 by The Royal Society

Landscape picture with respect to gene GATA6/NANOG for the stem cell network at different binding/unbinding speeds ω as well as different activation strength fB. Chunhe Li, and Jin Wang J. R. Soc. Interface 2013;10: ©2013 by The Royal Society

Changes of landscape topography of nine core node gene regulatory network of stem cell development at different binding/unbinding speeds ω when the activation regulation (class A activation, self-activation for both ES markers and differentiation markers) s... Chunhe Li, and Jin Wang J. R. Soc. Interface 2013;10: ©2013 by The Royal Society

Differentiation, reprogramming and transdifferentiation represented by 234 nodes (every node denotes a cell state, characterized by expression patterns of the nine marker genes) and 263 edges (transition paths) for slow regulatory binding/unbinding when ω =... Chunhe Li, and Jin Wang J. R. Soc. Interface 2013;10: ©2013 by The Royal Society

Illustration for major attractors and transition paths of cell fate decisions in non-adiabatic slow binding/unbinding conditions (ω = 0.01). Chunhe Li, and Jin Wang J. R. Soc. Interface 2013;10: ©2013 by The Royal Society

(a,b) The mean first passage time (MFPT) or kinetic transition time for cell type changes through differentiation, reprogramming and transdifferentiation when the binding/unbinding speed ω changes. Chunhe Li, and Jin Wang J. R. Soc. Interface 2013;10: ©2013 by The Royal Society