Approach to leucocytosis Jackie Thomson

ACUTE / IMMATURE

LYMPHOID MYELOID MATURE IMMATURE

LYMPHOID MYELOID MATURE IMMATURE

AML MDS AML MDS LYMPHOID MYELOID MATURE IMMATURE

CLL ALL LYMPHOMAS BURKITT LEUKAEMIA MYELOMA CLL ALL LYMPHOMAS BURKITT LEUKAEMIA MYELOMA AML MDS AML MDS LYMPHOID MYELOID MATURE IMMATURE

CLL ALL LYMPHOMAS BURKITT LEUKAEMIA MYELOMA CLL ALL LYMPHOMAS BURKITT LEUKAEMIA MYELOMA AML MDS AML MDS CHRONIC MYELOID LEUKAEMIA ESSENTIAL THROMBOCYTOSIS POLYCYTHEMIA VERA MYELOFIBROSIS CHRONIC MYELOID LEUKAEMIA ESSENTIAL THROMBOCYTOSIS POLYCYTHEMIA VERA MYELOFIBROSIS LYMPHOID MYELOID MATURE IMMATURE

Child Infections Leukemia most common ALL

Adult Good history: – Infection – B symptoms – Tierdness – Bleeding – Burning eyes – Skin

adult FBC NB look at platelets and HB Contact the hematologist when you have a clinical suspicion regarding patient Remember flow cytometry Fish Molecular testing

adult Exam: Look for spleen/ lymphnodes Mouth ulcers Auto immune /artritis erythromialgia