A DAPTING PUBLISHED RESEARCH DATA TO A BIOINFORMATICS MODULE IN A UNDERGRADUATE BIOLOGY MAJOR ’ S COURSE N ATURE M AY 26;473(7348): L ONG - TERM EVOLUTION AND TRANSMISSION DYNAMICS OF SWINE INFLUENZA A VIRUS. V IJAYKRISHNA D, ET AL. Natalia ToporikovaDenise Monti Carmen WrightSuzanne Hizer

A RESEARCH QUESTION TO DEFINE THE PROBLEM SPACE What changes occurred in the swine flu virus that allowed it to infect humans as H1N1 virus?

I DENTIFY THE PRIMARY INFLUENZA GENE THAT IS RESPONSIBLE FOR INFLUENZA TO BIND TO IT ’ S HOST CELL. Using MeSH terms to find primary research articles

W HAT DOES THIS GENE / PROTEIN DO ?

T HE PDB: MORE THAN JUST STRUCTURES

H OW IS YOUR GENE DIFFERENT OR THE SAME BETWEEN SWINE AND HUMAN H1N1?

E XPLORING THE ‘ MATH ’ BEHIND MULTIPLE SEQUENCE ALIGNMENTS BECASIS/abecasis.html

U SING PYTHON TO DEMONSTRATE SIMPLE SEQUENCE ALIGNMENT ALGORITHM

I DENTIFY THE VARIABLE REGIONS ON THE PROTEIN STRUCTURE FOR YOUR GENE

H OW DO YOU THINK THESE CHANGES ARE RESPONSIBLE FOR H1N1 INFECTIVITY IN HUMANS ?