This article and any supplementary material should be cited as follows: Asadi MR, Torkaman G, Hedayati M, Mofid M. Role of sensory and motor intensity.

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This article and any supplementary material should be cited as follows: Asadi MR, Torkaman G, Hedayati M, Mofid M. Role of sensory and motor intensity of electrical stimulation on fibroblastic growth facor-2 expression, inflammation, vascularization, and mechanical strength of full- thickness wounds. J Rehabil Res Dev. 2013:50(4):489–98. Slideshow Project DOI: /JRRD JSP Role of sensory and motor intensity of electrical stimulation on fibroblastic growth factor-2 expression, inflammation, vascularization, and mechanical strength of full-thickness wounds Mohammad Reza Asadi, MSc; Giti Torkaman, PhD; Mehdi Hedayati, PhD; Mahmood Mofid, MSc

This article and any supplementary material should be cited as follows: Asadi MR, Torkaman G, Hedayati M, Mofid M. Role of sensory and motor intensity of electrical stimulation on fibroblastic growth facor-2 expression, inflammation, vascularization, and mechanical strength of full- thickness wounds. J Rehabil Res Dev. 2013:50(4):489–98. Slideshow Project DOI: /JRRD JSP Aim – Evaluate effect of sensory and motor intensities of cathodal current on fibroblastic growth factor-2 (FGF-2) release at wound site and biomechanical and histological properties of healed skin. Relevance – Wound healing is complex biological process requiring interactions between cells. – Growth factors have key role in regulating these interactions.

This article and any supplementary material should be cited as follows: Asadi MR, Torkaman G, Hedayati M, Mofid M. Role of sensory and motor intensity of electrical stimulation on fibroblastic growth facor-2 expression, inflammation, vascularization, and mechanical strength of full- thickness wounds. J Rehabil Res Dev. 2013:50(4):489–98. Slideshow Project DOI: /JRRD JSP Method 96 healthy, male Sprague-Dawley rats randomized to 1 of 3 groups: – Sensory electrical stimulation (ES) 600 µA of DC applied 1 h/d every other day for 3, 7, or 21 days. – Motor ES 2.5 to 3 mA monophasic pulsed current with 300 μs pulse duration and 100 Hz frequency applied 1 h/d every other day for 3, 7, or 21 days. – Control Electrodes placed but no current delivered.

This article and any supplementary material should be cited as follows: Asadi MR, Torkaman G, Hedayati M, Mofid M. Role of sensory and motor intensity of electrical stimulation on fibroblastic growth facor-2 expression, inflammation, vascularization, and mechanical strength of full- thickness wounds. J Rehabil Res Dev. 2013:50(4):489–98. Slideshow Project DOI: /JRRD JSP Results FGF-2 levels in skin wound tissue: – Day 3 Significantly higher in sensory group than motor and control groups. Significantly lower in motor group than control group. – Day 7: Significantly lower in motor group than control group. No significant difference between sensory and control groups.

This article and any supplementary material should be cited as follows: Asadi MR, Torkaman G, Hedayati M, Mofid M. Role of sensory and motor intensity of electrical stimulation on fibroblastic growth facor-2 expression, inflammation, vascularization, and mechanical strength of full- thickness wounds. J Rehabil Res Dev. 2013:50(4):489–98. Slideshow Project DOI: /JRRD JSP Results Histological Results: – PNL proliferation: Lower in sensory than motor and control groups on days 3 & 7. – Mast cells: Significantly more in motor group than in sensory and control groups on day 3. – New blood vessels: Significantly more in motor group than control group on day 3. Biomechanical Results: – Day 21: Motor group had highest percent of normalized stiffness and strength (but no significant difference between groups).

This article and any supplementary material should be cited as follows: Asadi MR, Torkaman G, Hedayati M, Mofid M. Role of sensory and motor intensity of electrical stimulation on fibroblastic growth facor-2 expression, inflammation, vascularization, and mechanical strength of full- thickness wounds. J Rehabil Res Dev. 2013:50(4):489–98. Slideshow Project DOI: /JRRD JSP Conclusion Sensory ES during early wound healing releases angiogenic factors and decreases duration of inflammation. Motor ES during late stage of healing produces better results on collagen density and biomechanical properties of healed wound. Different intensities of ES should likely be applied for different stages of healing to obtain optimal effects.