“Top” Abstracts In No Particular Order 0034 – whole body muscular segmentation using multi-atlas techniques 0907 – Filippi et al.: damage to thalamic connectivity in MS using DTI metrics (52 RRMS) 1062 – myelin loss in thalamic pathways for TBI in rat, MTR is better than FA/DTI 0493 – VFA for simultaneous B1- and B1+ mapping 0447 – joint estimation of registration and T1 mapping for improved fits, general to all parametric mapping 0442 – T2* mapping, doing 2D acquisition with a 3D readout resolves artifacts 3395 – accuracy analysis for MRF 2825 – very similar to our project: thalamic segmentation using DTI and clustering and validation with gamma knife treatment of VLPv

52 RRMS, 57 controls Thalamic connectivity using diffusion tractography Group comparisons and random forests to predict cognitive impairment 22 patients were impaired – Increased FA of motor, post- central, and occipital thalamic CDRs – More atrophy in anterior thalamus Damage of specific cortico- thalamic tracts explained global and specific cognitive dysfunction better than all other MRI variables 0907 Probability maps of thalamic connectivity defined regions (CDRs) and cortico- thalamic tracts obtained from healthy controls.

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33 normals, 2 with GKS 3T, DWI w/ 64 directions, 2x2x2.5 mm 3 FreeSurfer to get whole thalamus on 1mm-iso. MPRAGE Features from orientation distribution functions in spherical harmonic basis – K-means clustering using spatial and SH distance, k=7 Gamma knife surgery of Vim for ET to validate VLV