ASSOCIATION OF HYPOVITAMINAEMIA D AND TRANSFORMING GROWTH FACTOR – β1 IN THE PROGRESSION OF CHRONIC KIDNEY DISEASE Grigorios G. Dimas 1, Ilias E. Kanellos.

Slides:

Advertisements

Similar presentations

UDETMA Mission: Reduce the incidence of cardiovascular disease Methodology of UDETMA: Use of noninvasive tests (carotid ultrasound, ankle-brachial index)

Advertisements

The Burden of Obesity in North Carolina Obesity-Related Chronic Disease.

Dr AP McGovern 1,2, Professor S de Lusignan 1, QICKD trial investigators 1 1 Clincal Informatics, Department of Healthcare Management and Policy, University.

Diabetes, Anemia and Chronic Kidney Disease Josephine Carlos-Raboca,M.D., F.P.S.E.M., Endocrinology, Diabetes and Metabolism Makati Medical Center.

KIDNEY FOUNDATION MISSION St. Gregorios Dayabhavan Kunigal.

TELBIVUDINE IS ASSOCIATED WITH IMPROVEMENT OF RENAL FUNCTION IN PATIENTS AFTER LIVER TRANSPLANTATION 1 Maria Ioannidou, 1 Evangelos Cholongitas, 2 Themistoklis.

On-going Research Studies in the Rosenfeld Lab *The role of RANK/RANKL in vascular complications of chronic kidney disease Effects of air pollution (diesel.

Role of Antiretroviral Therapy, Viral Replication, and HIV Infection in Atherosclerosis Priscilla Y. Hsue, Peter W. Hunt, Jeffrey N. Martin, Amanda Schnell,

Association of 1,5-Anhydroglucitol with Diabetes and Microvascular

Grigorios G. Dimas1, Thomas J. Tegos2, Fotios S. Iliadis1, Ilias E

Reference Cooper BA, and the IDEAL study group. A randomized controlled trial of early versus late initiation of dialysis. N Engl J Med [Accessed.

Use of clinical laboratory databases to enable early identification of patients at highest risk of developing end- stage kidney disease Dr David Kennedy.

Early detection of pulmonary involvement in scleroderma patients By Mohamed Mostafa Metwally, MD, FCCP Assistant professor of chest diseases Assiut University.

A significant proportion of diabetic patients develop diabetic nephropathy which can eventually progress to end-stage renal disease despite established.

Non-Surgical Periodontal Therapy Reduces Coronary Heart Disease Risk Markers: A Randomized Controlled Trial Bokhari SAH, Khan AA, Butt AK, Azhar M, Hanif.

Cystatin C– and Creatinine-Based Estimated Glomerular Filtration Rate, Vascular Disease, and Mortality in Persons With Diabetes in the U.S. Featured Article:

CASE 1. Donald is a 68 year-old man who is admitted to hospital via the Emergency Department one day, following a myocardial infarction. Subsequent investigation.

Psychiatric disorders after spine and craniocerebral injuries in amateur athletes N. Syrmos 1,3, V.Giannouli 2 A. Mylonas 3, Ch. Iliadis 1, V. Valadakis.

INTRODUCTION Dysregulation of Hypothalamic-Pituitary-Adrenal, (HPA), axis has been hypothesized to participate in the emergence of psychosis, yet findings.

Sense of coherence and carotid artery intima media thickness measurements: presenting four case reports from the Spili cohort in rural Crete, Greece D.

Coagulation / Fibrinolytic Factors in PCOS. The Alternative Hypothesis : Conversely, PCOS women may be protected from later life onset of CHD by the altered.

INTRODUCTION The stress diathesis hypothesis of psychosis is one of the most prevailing models of the aetiopathology of psychotic disorders. Cortisol is.

INCREASED CIRCULATING SERUM LEVELS OF MMP-9 AND VEGF-A ARE ASSOCIATED WITH OXIDATIVE STRESS IN PATIENTS WITH PRIMARY GLOMERULONEPHRITIS AND EARLY STAGES.

SERUM LEVELS OF IGF-1 IN FIRST EPISODE PSYCHOSIS AND CHRONIC SCHIZOPHRENIA PATIENTS COMPARED TO HEALTHY CONTROLS E. Ntouros 1, E. Karanikas 1, P. Ntafoulis.

ASSOCIATION OF CIRCULATING SERUM LEVELS OF VASCULAR ENDOTHELIAL GROWTH FACTOR-A WITH VASCULAR ULTRASOUND DETERMINANTS OF DEMENTIA IN PATIENTS WITH TYPE.

1 INTIMA MEDIA THICKNESS AND ATHEROSCLEROSIS Michele CAZAUBON, MD, PhD American Hospital of Paris ( France)

MENU ΣΤΕΦΑΝΙΑΙΑ ΝΟΣΟΣ ΣΕ ΔΙΑΒΗΤΙΚΟΥΣ ΚΑΙ ΗΛΙΚΙΩΜΕΝΟΥΣ.

Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 2 ARBITER-2 Trial Presented at The American Heart Association Scientific.

The tumour suppressor RhoB is an independent prognostic factor for metastasis in urinary bladder cancer. Apostolos Zaravinos 1, Dimitrios Volanis 1,2,

INCREASED CIRCULATING SERUM LEVELS OF TGFβ-1 AND IL-6 ARE ASSOCIATED WITH THE PROGRESSION OF CΗRONIC KIDNEY DISEASE IN ATHEROSCLEROTIC PATIENTS WITH TYPE.

MiR-21 can be used as independent prognostic factor for survival and metastasis in urinary bladder cancer. Apostolos Zaravinos 1, Jelena Radojicic 3, George.

Insulin Resistance Progression to Diabetes. Hypertension: BP >140/90 Dyslipidemia: ◦TG >150 mg/dL (1.7 mmol.L) ◦HDL-C

SERUM LEVELS OF TISSUE INHIBITOR OF METALLOPROTEINASE-2 AND OX-LDL ARE ASSOCIATED WITH ATHEROSCLEROSIS IN PATIENTS WITH CΗRONIC KIDNEY DISEASE Grigorios.

ANTIPLATELET TREATMENT IN PATIENTS WHO HAVE AN ISCHEMIC STROKE WHILE TAKING ASPIRIN Konstantinos Tziomalos, Stella D. Bouziana, Marianna Spanou, Stavroula.

FIBROBLAST GROWTH FACTOR-23 AND HYPOVITAMINAEMIA D IN ANAEMIA OF TYPE 2 DIABETIC NEPHROPATHY Grigorios G. Dimas 1, Fotios S. Iliadis 1, Ilias E. Kanellos.

Predicting Progression in Diabetic Nephropathy: New Biomarker: sTNFR1* Circulating soluble Tumor Necrosis Factor Receptor 1.

Relationship of cystatin C with Cardiovascular risk factors and inflammatory markers in Hemodialysis Hyung-Jong Kim, Kyung Mi Park, Yeon Hee Lee, Dong.

Comparison of Asymmetric DimethylArginine Levels and Coronary Artery Calcifications in Different Stages of Chronic Kidney Disease and Kidney Transplantation.

INCREASED CIRCULATING SERUM LEVELS OF TGFβ-1 AND MMP-2 ARE ASSOCIATED WITH INFLAMMATION AND PROGRESSION OF CΗRONIC KIDNEY DISEASE IN PATIENTS WITH TYPE.

Expression profile of oncomiRs and tumor-suppressor miRs in urothelial carcinoma of the bladder Apostolos Zaravinos 1, George I. Lambrou 2, Jelena Radojicic.

INCREASED CIRCULATING SERUM LEVELS OF VEGF-A ARE ASSOCIATED WITH ALBUMINURIA IN HYPETENSIVE PATIENTS Grigorios G. Dimas 1, Thomas J. Tegos 2, Ilias E.

DIABETES MELITUS, HYPERTENSION AND PARKINSON DISEASE IN A COMMON THREE LEAF CLOVER NEURODEGENERATIVE PATHWAY Grigorios G. Dimas 1, Charikleia T. Sachinidou.

Vitamin D: A New Frontier in Diabetes Management Contact Information: Background Acknowledgement Methods.

Risk Involved with Dual RAAS Blockade in Kidney Disease Source: Bakris GL. Dual RAAS blockade is desirable in kidney disease: Con. Kidney Int. 2010;78:546–549.

Template provided by: “posters4research.com” Levels of fasting blood glucose (p

Advanced Glycation End Products and Antioxidant Status in Type 2 Diabetic Patients With and Without Peripheral artery disease Annunziata Lapolla; Francesco.

RELATIONSHIP BETWEEN PARATHYROID HORMONE, VITAMIN-D, CALCIUM AND PHOSPHORUS IN CKD Neeraja Kunireddy, Priscilla Abraham Chandran, Sree Bhushan Raju, M.Noorjahan.

Prevalence of Chronic Kidney Disease among Older Adults in Urban Sri Lanka - Tip of the Iceberg? S T De Silva1,2, K T A A Kasturiratna3, S Chackrewarthy4.

3Neonatology, University of Miami, Miami, FL, USA

Common Carotid Artery Molecular Calcification Assessed by 18F-NaF PET/CT is Associated with Increased Cardiovascular Disease Risk: Results from the CAMONA.

－ Higher SBP visit-to-visit variability (SBV) has been associated

The LIVES Sub-analysis

Annals of Internal Medicine

Obesity Hypertension and Endothelial Dysfunction in Pediatric Patients

Poster Number 2842 Non-Calcified Coronary Artery Plaque Associates with Adverse Lipoprotein Profiles in Systemic Lupus Erythematosus. L. Durcan1, A.

Contribution of Oxidized Low Density Lipoprotein and Nitric Oxide in the Pathogenesis of Early Onset Acute Myocardial Infarction in Egyptian population.

CORRELATION OF BIOMARKERS FOR AXONAL DEGENERATION WITH RETINAL NERVE FIBER LAYER THICKNESS AND DISABILITY IN DIFFERENT PHASES OF MULTIPLE SCLEROSIS UZUNKOPRU.

Katarzyna Jobs, Anna Jung

Coagulation/Fibrinolytic Factors in PCOS

Risk of post-operative stroke in patients with known extra-cranial carotid artery disease undergoing Non-Cardiac Surgery Heart and Vascular.

Mean Platelet Volume (MPV), Neutrophil-to Lymphocyte Ratio (NLR) & Platelets-to-Lymphocyte Ratio (PLR) In association With Cardiovascular Disease In.

Prevalence of Chronic Kidney Disease among Older Adults in Urban Sri Lanka - Tip of the Iceberg? S T De Silva1,2, K T A A Kasturiratna3, S Chackrewarthy4.

Fig. 1. Intrarenal resistance index (RI) by stage of CKD (classification followed the K/DOQI guidelines [ 2 ]). Each box shows the median, quartiles and.

Figure 1 Types of coronary artery calcification

Lipoprotein (a) and Vascular Health in Children with Dyslipidemia

Frederik Persson, Peter Rossing Kidney International Supplements

Volume 61, Issue 3, Pages (March 2002)

Controls r=-0.82; P< GHD r=-0.84; P< Mean IMT (mm)

Correlation between endothelial function and hypertension

Volume 78, Issue 12, Pages (December 2010)

Presentation transcript:

ASSOCIATION OF HYPOVITAMINAEMIA D AND TRANSFORMING GROWTH FACTOR – β1 IN THE PROGRESSION OF CHRONIC KIDNEY DISEASE Grigorios G. Dimas 1, Ilias E. Kanellos 1, Fotios S. Iliadis 1, Thomas J. Tegos 2, Sofia G. Spiroglou 3, Ioannis M. Karamouzis 3, Christos G. Savopoulos 1, Apostolos I. Hatzitolios 1, Dimitrios M. Grekas st Propaedeutic Medical Department, AHEPA University Hospital, Aristotle University of Thessaloniki, Greece 2 1st Neurology Medical Department, AHEPA University Hospital, Aristotle University of Thessaloniki, Greece 3 Biochemistry Laboratory, AHEPA University Hospital, Aristotle University of Thessaloniki, Greece

Background The role of vitamin D in type 2 diabetes is well recognized, but its relation to glucose metabolism is not well studied. Transforming growth factor - β1 (TGF-β1) is involved nowadays in atherosclerosis and proteinuria. The aim of the present study was to determine the serum levels of 1.25(OH) 2 D 3 and TGF-β1 and to investigate their potential correlation with atherosclerotic markers and albuminuria in early stages of chronic kidney disease (CKD).

Aim The aim of the present study was to determine the serum levels of 1.25(OH) 2 D 3 and TGF-β1 and to investigate their potential correlation with atherosclerotic markers and albuminuria in early stages of chronic kidney disease (CKD).

Methods CKD patients of stages 1 and 2 (n=50) were included. As controls, there were healthy individuals (n=40). 1.25(OH) 2 D 3 and TGF-β1 levels were measured by an ELISA method. Intima media thickness (IMT) of carotid and femoral arteries and atheromatic plaque were evaluated by a high resolution ultrasonography.

Results There was a statistically significant difference between TGF-β1 (11000±500, p<0.0001), 1.25(OH) 2 D 3 (40±3, p<0.0001), albuminuria (300±150, p<0.0001) and IMT (0.4±0.1, p<0.0001) between patients and controls. There was a statistically significant positive strong correlation between levels of TGF-β1 and IMT (r= 0.75, p<0.0001) and TGF-β1 and albuminuria (r= 0.7, p<0.0001) in the patient group. There was also a statistically negative strong correlation between 1.25(OH) 2 D 3 and IMT (r= -0.7, p<0.0001), 1.25(OH) 2 D 3 and albuminuria (r= -0.75, p<0.0001) and 1.25(OH) 2 D 3 and TGF-β1 (-0.65, p<0.0001) in the patient group. Further, TGF-β1 and 1.25(OH) 2 D 3 levels were independently correlated with albuminuria, IMT and atheromatic plaque.

Conclusion Our study suggests that serum levels of TGF-β1 and 1.25(OH) 2 D 3 might present independent risk factors of atherosclerosis and albuminuria in CKD.