Rumex International Co. Bridge between innovative technology and perfect surgery Rumex International Company th Street North, Suite 317 Clearwater, FL 33760, USA

2 Rumex OVDs. SmartVisc, SmartVisc+ CE Marked November ml

3 SmartVisc, SmartVisc+ Are viscoelastics based on sodium hyaluronate from biotechnical fermentation and are free of pyrogenic substances. SmartVisc 1.6% Sodium hyaluronate SmartVisc+ 3.0% Sodium hyaluronate

4 SmartVisc, SmartVisc+ Will help you maintain the important working space! * Ability to deepen the anterior and posterior chambers to allow for easier capsulorhexis and lens implantation * Excellent tissue manipulation * Completely transparent to enhance visualisation during cataract and vitreoretinal surgery * Asrpiration is quick and easy. Additionally, there is less chance for trapped viscoelastic behind the optic.

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6 SmartVisc 1,6% Technical data: Sodium Hyaluronate: Molecular Weight: Viscosity: Osmolarity: Storage: pH: Volume: Shelf life Cannula 1.6% 1.2 – 2.0 mill. Daltons aprox mPs mOsm/kg 2 – 25°C ml 3 years 27 gauge Formula: 1 ml contains Sodium hyaluronate Sodium chloride Disodium hydrogenphosphate Sodium dihydrogenphosphate Water for injection mg mg mg mg q.s High cohesion for easy irrigation / aspiration Soft coating and protection of endothelial cells

7 SmartVisc + 3.0% Technical data: Sodium Hyaluronate: Molecular Weight: Viscosity: Osmolarity: Storage: pH: Volume: Shelf life Cannula 3.0 % average million Dalton aprox mPs 270 – 400 mOsm/kg 2 – 25°C ml 3 years 27 gauge Formula: 1 ml contains Sodium hyaluronate Sodium chloride Disodium hydrogenphosphate Sodium dihydrogenphosphate Water for injection mg mg mg mg q.s. High cohesion for easy irrigation / aspiration Soft coating and protection of endothelial cells High Viscosity

8 Features Two different viscosities (80&400) can provide Viscoelastic Soft Shell Technique Low molecular weight - easy to remove after surgery Ultrapure Hyaluronic Acid with highest biocompatibility Clear view of posterior capsule during phacoemulsification No refrigeration necessary – storage 2-25° Volume: 1 ml

9 Competitors in the global market BrandProducerVolume of Syringe MW (D)CompositionStorageCohesiveDispersive ProviscAlcon Labs, USA 0.4;0.55; % NaHa2-8°C+- ViscoatAlcon Labs, USA % NaHa, 4 % CDS 2-8°C-+ DisCoviscAlcon Labs, USA 0.5; % NaHa, 4 % CDS 2-8°C++ HealonAMO, USA0.4;0.55; % NaHa2-8°C+- Healon GVAMO, USA0.55; % NaHa2-8°C+- Healon 5AMO, USA % NaHa2-8°C++ AmviscBausch&Lomb, Incorporated, USA % NaHa2-8°C+- Amvisc PlusBausch&Lomb, Incorporated, USA % NaHa2-8°C+- MultiviscBVI, USA % NaHa2-8°C++ OVD1.2%BVI, USA % NaHa2-8°C+- SmartViscRumex Int. Ltd, UK % NaHa2-25 °C+- SmartVisc+Rumex Int. Ltd, UK % NaHa2-25 °C+-

10 Rumex OVDs. SUPREME CE Marked November 2011 Supreme is a viscoelastic solution of high molecular weight, highly purified grade of hydroxypropyl methylcellulose 2%, clear, isotonic, sterile, non inflammatory and non-pyrogenic in nature. It is used for intraocular injection during anterior segment surgery of the eye.

11 Product Features Supreme is a medical device used in the anterior segment surgery of the eye. It has the following unique characteristics:

12 Properties: Molecular Weight86,000 daltons Dynamic Viscosity 3000 – 4500 cPs at 27 ⁰ C pH6.0 – 7.8 Osmolality mosmol/Kg Volume2 ml pre-filled glass syringes in double pouch packing

13 Competitors in the global market BrandProducerVolume of Syringe (ml) CompositionViscosity (mPas) MW (D) CellugelAlcon Labs., USA) 1.02% НРМС30 000± OcucoatBausch & Lomb, USA 2.02% НРМС4000 ± AppaviscAppasamy, India % НРМС Metilon20BioTech, India2.02% НРМС Metilon24BioTech, India2.02.4% НРМС SupremeRumex Inc. Ltd, UK 2.02% НРМС

14 Rumex International Company th Street North, Suite 317 Clearwater, FL 33760, USA USA, Canada: Tel: +1 (727) Toll Free: +1 (877) 77 RUMEX Fax: +1 (727) Europe, Asia, Africa, Latin America: Tel: