Beginning of the chapter Prostate cancer and genetics (Prostate Health Sensor) 25.

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Presentation transcript:

Beginning of the chapter Prostate cancer and genetics (Prostate Health Sensor) 25

SENSORS PROSTATE HEALTH SENSOR Prostate hyperplasia & prostate cancer

PROSTATE CANCER Polymorphisms The 10 polymorphisms that influence the risk of prostate cancer

PROSTATE CANCER Polymorphisms

PROSTATE CANCER Polymorphisms

PROSTATE CANCER Polymorphisms

PROSTATE CANCER Polymorphisms

PROSTATE CANCER The optimal genetic profile: Odds Ratio = 1 The worst genetic profile: Odds Ratio = 359 The average genetic profile: Odds Ratio = 5.9 OR 1 OR 6 OR 359 The relative risk of prostate cancer

PROSTATE CANCER The usefulness of genetic analysis 1) Prevention 2) Early detection 3) Better treatment

PROSTATE CANCER Genetic risk, what to do now? Prevention: Avoid high calories and high fat (animal) products Practice regular exercises Avoid the alcohol, as risk factor Follow a diet rich in vitamin D

PROSTATE CANCER The usefulness of genetic analysis 1) Prevention 2) Early detection 3) Better treatment

PROSTATE CANCER Genetic risk, what to do now? Prevention: Avoid high calories and high fat (animal) products Practice regular exercises Avoid the alcohol, as risk factor Follow a diet rich in vitamin D EARLY DETECTION: Earlier, more often, more thoroughly PSA level determination and monitoring Bladder emptying studies Pay attention to symptoms of prostate enlargement

PROSTATE CANCER The usefulness of genetic analysis 1) Prevention 2) Early detection 3) Better treatment

PHARMACOGENETICS Various drugs and enzymes DRUG D 3A42C192E9 3A5 NAT2 DRUG C 2D6 DRUG B 2C9 DRUG A 1A2 break down

PROSTATE CANCER Prostate cancer treatment

End of the chapter Prostate cancer and genetics (Prostate Health Sensor) 25