Amino Acids Stryer Short Course Chapter 3. Amino Acid Structure Alpha carbon Sidechain Proteins peptides.

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Presentation transcript:

Amino Acids Stryer Short Course Chapter 3

Amino Acid Structure Alpha carbon Sidechain Proteins peptides

Stereochemisty L-amino acids – Glycine – R/S vs D/L – L-isoleucine racemization

Ionization of Amino Acids Polyprotic acids Alanine – pKa 1 = 2.4 – pKa 2 = 9.9 Zwitterion Isoelectric point More acidic than typical carboxylic acid

Polyprotic Acids

Common Amino Acids

Hydrophobic Or polar

Hydrophobic

Polar

Positively Charged Or polar

Negatively Charged

Acid/base chemistry Charged amino acids Other amino acids are ionizable

Which amino acid(s)... Is achiral? Has a secondary amino group? Has a chiral sidechain? Form these derivatives:

Titration Curve

Which amino acid?

Ionization States Of Amino Acids A B C D E F G

Essential Amino Acids Dietary Term Can change in stage of life Depends on definition of biosynthetic building blocks