The pathogenesis of Plasmodium falciparum malaria in humans: insights from splenic physiology by Pierre A. Buffet, Innocent Safeukui, Guillaume Deplaine,

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Presentation transcript:

The pathogenesis of Plasmodium falciparum malaria in humans: insights from splenic physiology by Pierre A. Buffet, Innocent Safeukui, Guillaume Deplaine, Valentine Brousse, Virginie Prendki, Marc Thellier, Gareth D. Turner, and Odile Mercereau-Puijalon Blood Volume 117(2): January 13, 2011 ©2011 by American Society of Hematology

The splenon the functional unit of splenic RBC filtration. Pierre A. Buffet et al. Blood 2011;117: ©2011 by American Society of Hematology

Structure-function correspondences in the slow, open microcirculation. Pierre A. Buffet et al. Blood 2011;117: ©2011 by American Society of Hematology

Interactions of P falciparum–infected RBCs with the microcirculation, and with the spleen during acute and chronic infection in patients with normal or impaired splenic function. Pierre A. Buffet et al. Blood 2011;117: ©2011 by American Society of Hematology

Ability of RBCs to cross the spleen, dispersion of individual values, and possible variability of the splenic detection threshold in the context of P falciparum infection. Pierre A. Buffet et al. Blood 2011;117: ©2011 by American Society of Hematology