Revascularizaton of Ischemic DCM Percutaneous Revascularization and Hemodynamic Support Matthew R. Wolff, M.D. University of Wisconsin Disclosures: Cordis / Johnson and Johnson Abbott
Patient E.T. 84 y.o. retired game warden 6 month history of progressive dyspnea (~15 feet), orthopnea, PND No angina Echo: dilated cardiomyopathy EF = 20% Moderate CRF Cr = 2.0 mg/dl Occluded left internal carotid artery
Percutaneous LVAD (TandemHeart TM ) Logistic Euroscore 36.8 %
Percutaneous LVAD insertion (TandemHeart TM ) 21 Fr. Left atrial inflow cannulae 15 or 17 Fr. Femoral arterial outflow catheter 4 – 4.5 L/min flow
AHA Heart Disease and Stroke Statistics – 2005 Update Prevalence of Congestive Heart Failure by Age (NHANES 1999 – 2004)
Hemodynamic Support for High-Risk PCI Pressors and intravenous inotropes IABP Reduced afterload Increased diastolic perfusion pressure Increased forward flow - MODEST Percutaneous Left Ventricular Assist
TandemHeart Support for Elective PCI in High-Risk Ischemic DCM at UW (11/21 cases from ) Preoperative Characteristics Age (yrs)73 ± 14 Unprotected LMCA5/11 EF (%)24 ± 8 Logistic Euroscore (30 d mortality, %) 32 ± 19
TandemHeart Support for Elective PCI in High-Risk Ischemic DCM Procedural Outcome Procedural Time (min)170 ± 37 Time to Pump (min)45 ± 6 Preclose/Hemostasis in Lab11/11 Mean Flow (L/min)3.1 ± 0.2 Vessels Treated2.3 ±1.2 Stents Deployed3.8 ± 1.7
TandemHeart Support for Elective PCI in High-Risk Ischemic DCM Hospital Course 30 day Survival10/11 Vascular Complications (Transfusion) 1/11 Other Complications (Atrial Lead Dislodged) 1/11
TandemHeart Support for Elective PCI in High-Risk Ischemic DCM Mean Follow up 20 ± 11 Months Survival (%)73 (deaths at 3, 4, 4 months) EF (%)44 ± 7
TandemHeart Support for Elective PCI in High- Risk Ischemic DCM ( 7 Survivors with ≥ 12 month F/U)
Indications for pLVAD High-risk PCI Cardiogenic shock AMI Decompensated chronic heart failure Post-op CABG RV support RV infarct Post-op CABG Bi-ventricular failure with LVAD
Impella Recover LP 2.5 System NOT FOR SALE IN THE UNITED STATES *Caution: Investigational Device, limited by Federal law to Investigational Use 12 Fr Distal 2.5 L/min flow
Who to Revascularize? Myocardial Viability Clinical– angina MRI PET Thallium Dobutamine Echo
Tarakji, K. G. et al. Circulation 2006;113: Propensity-matched patients undergoing PET viability testing (306/765) at the Cleveland Clinic
Tarakji, K. G. et al. Circulation 2006;113: Association between predicted 3-year mortality and the amount of compromised viable myocardium (ischemic and hibernating) determined by PET/FDG study according to performance of early intervention among propensity-matched patients
Copyright ©2001 American College of Cardiology Foundation. Restrictions may apply. Berger, P. B. et al. J Am Coll Cardiol 2001;38: How to revascularize? BARI Survival curves of patients with three-vessel disease and reduced ventricular function undergoing percutaneous transluminal coronary angioplasty (PTCA) and coronary artery bypass graft (CABG) in the Bypass Angioplasty Revascularization Investigation
Copyright ©2001 American College of Cardiology Foundation. Restrictions may apply. Morrison, D. A. et al. J Am Coll Cardiol 2001;38: AWESOME Kaplan-Meier survival plot of coronary artery bypass graft surgery (CABG) (circles) versus percutaneous coronary intervention (PCI) (squares)
Copyright ©2001 American College of Cardiology Foundation. Restrictions may apply. Morrison, D. A. et al. J Am Coll Cardiol 2001;38: AWESOME Kaplan-Meier plot of survival free of unstable angina (UA) or repeat revascularization for coronary artery bypass graft surgery (CABG) (circles) versus percutaneous coronary intervention (PCI) (squares)
DES in Higher Risk Settings
DES vs CABG Trials Syntax Cardia Freedom
Percutaneous Therapy for DCM PCI (with or without hemodynamic support) Percutaneous valve therapies Cellular therapies