Butte Lab Journal Club 4/19/10 Linda Liu

- DNA sequenced by Complete Genomics - Advantages of family-based sequencing as opposed to sequencing unrelated individuals: - sequencing error detection - identify precise recombination spots - estimation of mutation rate - much smaller search space for candidate disease mutations - Mutation rate estimate of 1.1x10-8 per position per haploid genome, corresponding to approximately 70 new mutations in each diploid human genome

- 155 crossover sites (98 from maternal meioses, 57 from paternal meioses)

- Sequenced the genomes of E. coli clones sampled at generations 2,000, 5,000, 10,000, 15,000, 20,000 and 40,000 from an asexual population that evolved with glucose as a limiting nutrient for almost 20 years

Methylation

Sex Differences