Biosynthesis of Amino Acids. Overview Overview (cont)

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Biosynthesis of Amino Acids

Presentation transcript:

Biosynthesis of Amino Acids

Overview

Overview (cont)

Biosynthetic Families Metabolic PrecursorsAmino Acids  -ketoglutarateGlutamate Glutamine Proline Arginine 3-PhophoglycerateSerine Glycine Cysteine

Biosynthetic Families (cont) Metabolic PrecursorsAmino Acids OxaloacetateAspartate, Asparagine Methionine, Threonine, Lysine PyruvateAlanine, Valine, Leucine Isoleucine

Biosynthetic Families (cont) Metabolic PrecursorsAmino Acids PhosphoenolpyruvateTryptophan and erythrose 4-phosphate Phenlyalanine Tyrosine Ribose 5-phophateHistidine

 Ketoglutarate Family  Ketoglutarate Glutamate GlutamineProlineArginine

 -Ketoglutamate to glutamate/glutamine Glutamate + NH ATP Glutamine synthetase Glutamine + ADP + Pi + H +  -Ketoglutamate + glutamine + NADPH + H + Glutamate synthase 2 glutamate + NADP +

 -Ketoglutamate to glutamate/glutamine Net Reaction:  -Ketoglutarate + NH NADPH + ATP L-glutamate + NADP + + ADP + Pi

 Ketoglutarate Family  Ketoglutarate Glutamate GlutamineProlineArginine

Synthesis of Proline

Synthesis of Arginine

3-Phosphoglycerate Family 3- Phosphoglycerate Serine GlycineCysteine

Synthesis of Serine and Glycine

Synthesis of Cysteine

Oxoloacetate Family Oxaloacetate Aspartate AsparagineMethionineLysineThreonine

Synthesis of Aspartate and Asparagine Oxaloacetate Aspartate Transamination from glutamate Amidation with Glutamine donating NH 4 + Asparagine

Synthesis of Lysine, Methionine, and Threonine See handout

Pyruvate Family Pyruvate AlanineValineLeucineIsoleucine

Synthesis of Alanine Pyruvate Alanine Transamination from glutamate

Synthesis of Isoleucine, Valine,and Leucine See handout

Phosphoenolpyruvate and erythrose 4-phosphate Family Phosphoenolpyruvate + erythrose 4-phosphate Chorismate TryptophanTyrosinePhenylalanine

Synthesis of Chorismate

Synthesis of Tryptophan

Synthesis of Tyrosine and Phenylalanine

Synthesis of Tyrosine and Phenylalanine (cont)

Biosynthesis of Histidine See handout

Possible Test Questions 1)Provide the 6 metabolic precursors and the amino acids which they lead to. 2)Duplicate the Amino Acid Synthesis Overview Flow Chart. Expand the sections need to show the synthesis of Glutamate, Glutamine, Proline, Arginine, Serine, Cysteine, Glycine, and starting from Chorismate Tryptophan, Tyrosine and Phenylalanine. (40 points!!)