1 Impact of Bioinformatics in our life and BME engineer responsibility Dr Fadhl Alakwaa fadhl-alakwa.weebly.com

OUTCOMES Why human Look differentthan Chimpanzee? /12/2013

OUTCOMES Why do we look different ? /12/2013

OUTCOMES Why our body is very complicated? /12/2013

OUTCOMES How much we know about our biological system? /12/2013

OUTCOMES What is our role in solving life big mystery? BME /12/2013

DNA Our cell is the basic unit of our body /12/2013

DNA is composed of nucleotides 88 2 Phosphate Sugar Nitrogenous base A 10/12/2013

There are 4 nucleotide A G C T DNA is composed of nucleotide 99 3 Phosphate Sugar Nitrogenous base AA T G C 10/12/2013

10 A T G C 5 P’3OH’ A T G C A T G C 53 4 DNA is composed of millions of nucleotides 10/12/2013

11 A C G T A C G T A C G T A C G T No of base pairs= Genome Size HG= 3200 Mbp (Mb) 5 DNA is double strand connected with hydrogen bounds 10/12/2013

12 6 DNA size= Genome size 10/12/2013

13 SEQ 1: AAAATTTTTTGGGGGGGGCCCCCCCCCCCCCCCCCC 7 How many different sequences we get? SEQ 2: AAAATTTTTTGGGGGGGGCCCCCCCCCCCACCCCCC SEQ N: AAAATTTTTTGGGGGGGGCCCCCCCCCCCCCCCCCA 10/12/2013

14 SEQ 1: AAAATTTTTTGGGGGGGGCCCCCCCCCCCCCCCCCC 7 How many different sequence we get? SEQ 2: AAAATTTTTTGGGGGGGGCCCCCCCCCCCACCCCCC SEQ N: AAAATTTTTTGGGGGGGGCCCCCCCCCCCCCCCCCA 4^ 3200 X10^6 10/12/2013

OUTCOMES Yes we are different because we came from different sequence. Twins has the same DNA sequence /12/2013

16 SEQ 1: AAAATTTTTTGGGGGGGGCCCCCCCCCCCCCCCCCC 8 Data bases for all organism SEQ 2: AAAATTTTTTGGGGGGGGCCCCCCCCCCCACCCCCC SEQ N: AAAATTTTTTGGGGGGGGCCCCCCCCCCCCCCCCCA 4^ 3200 X10^6 10/12/2013

Start on End on 17 9 The Human genome project 10/12/2013

18 10 Data bases for all organism The data bases sizes, logos 10/12/2013

OUTCOMES What is our role in solving life big mystery? BME Search and storage Sequence alignment 3D structure predication Computational biology System biology Bioinformatics Gene function ontology Drug discovery /12/2013

OUTCOMES Why human Look differentthan Chimpanzee? /12/2013

OUTCOMES What is our role in solving life big mystery? BME DNA sequencer M-RNA analysis PCR Electrophoresis /12/2013

Cell function = proteins Protein is composed of amino acids 22 1 Amino acid AA F N G G S T S D K COO - NH 3 + C R H Amino groupCarboxylic acid group 10/12/2013

23

Protein is synthesized from genes 24 2 Genes located on DNA AA F N G G S T S D K 10/12/2013