Margarita Valero Juan Physical Chemistry Department Pharmacy Faculty Salamanca University Micelles as Drug Carriers for Controlled Release ATHENS 2014

SALAMANCA, SPAIN Margarita Valero

SALAMANCA MAIN SQUARE

SALAMANCA CATHEDRAL

PHARMACY FACULTY

Physical Chemistry Department

1.- Colloidal Systems Dispersed particles (10 -6 m to m) (  -nm) SolutionsMacrodispersions Dispersed particles: A: liophilic: are soluble in the dispersant medium: aggregation colloids or polymers B: liophobic: are not soluble in the dispersant medium: -emulsions (liquid/liquid) -suspensions (solid/liquid)

2.- Micelles Formation APOLARPOLAR INNER SOLUTION (DISSOLVED) INTERFACE (ADSORBED) HYDROPHOBIC SURFACE HYDROPHYLIC SURFACE

NON IONICS IONICS H2OH2O H2OH2O H2OH2O H2OH2O H2OH2O H2OH2O H2OH2O H2OH2O H2OH2O H2OH2O H2OH2O H2OH2O H2OH2O H2OH2O H2OH2O H2OH2O “PALISADE LAYER” x+x+ x+x+ x+x+ x+x+ x+x+ x+x+ x+x+ x+x+ - x+x x+x+ x+x+ x+x+ x+x+ FIX LAYER:”STERN ” DIFUSSE LAYER:”GOUY ” DOBLE ELECTRIC LAYER : “GOUY CHAPMAN” Electrical Potential Potential Value:Zeta potenlial (ξ) 3.- Stucture of Micelles

LOADDING + molecules polarity KPKP K P : Partition KP=KP= [molecule] micelle [molecule] H 2 O 4.- Properties of Micelles

MICROEMULSIÓN 5.- Solubilization and Microemulsions

6.- Other Types of Micelles and Aggregates

PHOTOPHYSICS PROCESSES  = PHOTONS DEACTIVATED ABSORBED PHOTONS  : lifetime max F em  abs = Stokes Shift * QUENCHIG 6.- Fluorescence Spectroscopy

BIOLUMINISCENCE

BIOLUMINISCENCE

BIOLUMINISCENCE

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