Subgroup Vitamin C Active Group Placebo Group P value for Interaction Age yr (No. of cases) yr  65 yr <  BMI High, >1000kcal/wk Low,  1000kcal/wk Physical Activity Current Past Never Cigarette Smoking 0.05 Never/rarely  1 drink/mon Alcohol Intake 0.26 Premenopausal Uncertain Postmenopausal, current HT use Menopausal status and HT use 0.14 Postmenopausal, no HT use Yes No Family History of diabetes 0.63 Yes No History of Hypertension 0.17 Yes No History of Hypercholesterolemia 0.01 Tertile 1 ( ) Tertile 2 ( ) Dietary vitamin C intake (mg/d) 0.99 Tertile 3 ( ) Relative Risk for Type 2 Diabetes A Supplemental Figure 1.

Relative Risk for Type 2 Diabetes Subgroup Vitamin E Active Group Placebo Group P value for Interaction Age yr (No. of cases) yr  65 yr <  BMI High, >1000kcal/wk Low,  1000kcal/wk Physical Activity Current Past Never Cigarette Smoking 0.57 Never/rarely  1 drink/mon Alcohol Intake 0.57 Premenopausal Uncertain Postmenopausal, current HT use Menopausal status and HT use 0.27 Postmenopausal, no HT use Yes No Family History of diabetes 0.30 Yes No History of Hypertension 0.58 Yes No History of Hypercholesterolemia Supplemental Figure 1. Tertile 1 ( ) Tertile 2 ( ) Dietary vitamin E intake (IU/d) Tertile 3 ( ) B

Subgroup  -Carotene Active Group Placebo Group P value for Interaction Age yr (No. of cases) yr  65 yr <  BMI High, >1000kcal/wk Low,  1000kcal/wk Physical Activity Current Past Never Cigarette Smoking 0.57 Never/rarely  1 drink/mon Alcohol Intake 0.57 Premenopausal Uncertain Postmenopausal, current HT use Menopausal status and HT use 0.27 Postmenopausal, no HT use Yes No Family History of diabetes 0.30 Yes No History of Hypertension 0.58 Yes No History of Hypercholesterolemia Tertile 1 ( ) Tertile 2 ( ) Dietary total carotene intake (mg/d) Tertile 3 ( ) Relative Risk for Type 2 Diabetes Supplemental Figure 1. C