Fig. 26.1 Predicted permeation pore helix and selectivity filter of human TRPV subfamily. Left panel shows a partial alignment of the primary structure.

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Fig Predicted permeation pore helix and selectivity filter of human TRPV subfamily. Left panel shows a partial alignment of the primary structure of members of the TRPV family including the permeation zone, selectivity filter (light green) and P-loop (orange), transmembrane domain 6 (TM6) (light red). Right. Molecular model of the human TRPV1 pore domain ([91]; coordinates drawn using PyMol molecular graphics program). The different regions are colored to match the color code used in the left panel. The selectivity filter residues (TIGMGD) are highlighted in sticks representation Transient Receptor Potential Channels, Md. Shahidul Islam (Ed.) ISBN: , Springer

Fig Energy barrier profile Transient Receptor Potential Channels, Md. Shahidul Islam (Ed.) ISBN: , Springer

Fig Structural components involved in temperature activation of TRPV1. This molecular model shows the external aspect of the TRPV1 pore, highlighting the turret and the amino acids residues that have been implicated in temperature detection Transient Receptor Potential Channels, Md. Shahidul Islam (Ed.) ISBN: , Springer

Fig The basic residues present in TM4 and in the TM4-TM5 linker in thermo-TRPs Transient Receptor Potential Channels, Md. Shahidul Islam (Ed.) ISBN: , Springer

Fig Sequential and allosteric kinetic models. (a) A five state sequential model with four closed states, C 0, C 1, C 2 and C 3, and a single open state O. (b) Monod-Wyman-Changeaux (MWC) model after Voets et al. [4], used to explain channel activation by agonists. (c) Allosteric model of TRP channel activation by voltage and temperature. (d) A general gating mechanism includes an allosteric interaction between channel opening (described by the equilibrium constant L), voltage sensor activation (described by the voltage-dependent equilibrium constant J), temperature sensor activation (described by the temperature-dependent equilibrium constant K) and agonist activation (described by the equilibrium constant Q) Transient Receptor Potential Channels, Md. Shahidul Islam (Ed.) ISBN: , Springer