Regulating the Cell Cycle Controls on cell division

Normally developing cells Demonstrate anchorage dependence Demonstrate anchorage dependence Demonstrate density dependent inhibition Demonstrate density dependent inhibition Are stimulated to grow by growth factors Are stimulated to grow by growth factors

Proteins regulation Proteins called cyclins regulate the timing of the cell cycle in normal eukaryotic cells Proteins called cyclins regulate the timing of the cell cycle in normal eukaryotic cells Other regulatory proteins includes internal & external regulators Other regulatory proteins includes internal & external regulators

Uncontrolled cell growth Cancer, a disease where cells do not have a properly functioning cell-cycle control system Cancer, a disease where cells do not have a properly functioning cell-cycle control system As a result, tumors form which may be malignant or benign. As a result, tumors form which may be malignant or benign. Malignant=cancers=cell growths where the cells are replicating without any inhibition of cell growth….will cause death of the organism if allowed to continue growing Malignant=cancers=cell growths where the cells are replicating without any inhibition of cell growth….will cause death of the organism if allowed to continue growing

Understanding cancer cont’d.. Benign: excessive cell growth that will not cause significant harm to the organism Benign: excessive cell growth that will not cause significant harm to the organism Metastasis-the spread of the cancer beyond its original site Metastasis-the spread of the cancer beyond its original site Common cancers: Where are they? Common cancers: Where are they? Carcinoma, Osteomas, Leukemias, Carcinoma, Osteomas, Leukemias, Lymphomas Lymphomas

Virtual Lab Review: What are leading cancers in this country? What are leading cancers in this country? What are believes causes for them? What are believes causes for them?