Cancer MetaData Standards Peter A. Covitz, Ph.D. HL7 RCRIM October 1, 2002.

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Presentation transcript:

Cancer MetaData Standards Peter A. Covitz, Ph.D. HL7 RCRIM October 1, 2002

NCI Center for Bioinformatics Established in early 2001 by Kenneth Buetow Folded in several existing programs, launched new ones Mission to bridge basic and clinical research via biomedical- informatics

caCORE Core Infrastructure for biomedical application development NCI Enterprise Vocabulary Services Thesauri and Ontologies Bioinformatics Infrastructure Objects UML-modeled middleware and APIs Cancer Data Standards Repository Metadata

NCICB-supported initiatives Cancer Genome Anatomy Project ESTs, SAGE, SNPs, Pathways Molecular Signatures of Cancer Microarray-based tumor classification Mouse Models of Human Cancer Consortium Pathology, microarray Clinical Trials Protocols, agents, targets, patient cases

Cancer Data Standards Repository Metadata management system for NCI Common Data Elements

Cancer Data Standards Repository (caDSR) Registry for Common Data Elements Implemented in Oracle DBMS Logically separate Contexts caDSR Tools: CDE Form Compliance Review CDE Browse/Query/Export CDE Curation caDSR Programming Interfaces: PL/SQL XML

ISO/IEC Model Contexts Conceptual Domains Data Element Concept Value DomainPermissible Values Data Element Administered Component Status Administered Component Classification Schemes Classification Schemes Items

Example CDEs Context:NCI-CTEP Data Element Concept: Person Age Data Elements: Patient Age - Number (3,1) Patient Birthday – Date Conceptual Domain:AGE Value Domains:YearsMonthsDates Permissible Values 0 – /01/ /01/2150

Common Data Element Contexts Different Curators for each Context

CDEs in Production Therapeutic Phase III Cancer trials Extramural trials overseen by NCI-CTEP must transmit data to the using CDEs Prevention Trials NCI-Division of Cancer Prevention NCI Intramural Trials NCI Center for Cancer Research Spiral CT trial NCI Biomedical Imaging Program and partners

caDSR Next Steps Tool and Interface Completion Additional CDE Domains Pediatrics Phase I/II Trials Genomics Harmonization of CDEs... Across Contexts, if it makes sense to do so With Public Standards (HL7, LOINC, etc.)

HL7 Seeking for suggestions on how to harmonize with HL7 CDEs as part of HL7 messages? What are the “metadata” adoption mechanisms for HL7?

Acknowledgements Kenneth Buetow Denise Warzel Beverly Meadows Jeff Abrams Christo Andonyadis Jasur Ishmukhamedov Ram Chilukuri Prerna Aggarwal Bill McCurry Claudine Valmonte Pam West Mary Supley

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