Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders

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Presentation transcript:

Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders Chapter 18

Schizophrenia Schizophrenia is a term coined by Eugene Bleuler in 1911 to describe a collection of illnesses characterized by thought disorders Psychotic episode Genetic predisposition Prenatal and perinatal Neuroanatomic alterations Neurotransmitter alterations

Schizophrenia

Schizophrenia

Schizophrenia Clinical manifestations Hallucinations Delusions Disorganized behavior Disorganized speech Negative symptoms Affective flattening Anhedonia, alogia, and avolition

Mood Disorders Mood refers to a sustained emotional state Affective states are brief emotional feelings Euphoria, joy surprise, fear, sadness, etc. Depression States such as sadness become prominent

Mood Disorders Categories of mood disorder Genetic predisposition Unipolar Also known as major depression or clinical depression Bipolar disorder Genetic predisposition Environmental influences

Mood Disorders Neurochemical dysregulation Neuroendocrine dysregulation Hypothalamic-pituitary-adrenal system dysregulation Hypothalamic-pituitary-thyroid system dysregulation Neuroanatomic and functional abnormalities

Mood Disorders Clinical manifestations Treatment Depression Mania Antidepressants Psychotherapy Combination of both

Mood Disorders

Mood Disorders

Anxiety Disorders Panic disorder Generalized anxiety disorder Posttraumatic stress disorder Obsessive-compulsive disorder

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