Hypersensitivity Reactions. Injurious, patologic immune reactions causing tissue injury and disease Excessive or aberrant immune response to: Foreign.

Slides:



Advertisements
Similar presentations
Lecture outline Types of hypersensitivity reactions
Advertisements

Type II Hypersensitivity: Antibody-mediated cytotoxicity
Immunity, Hypersensitivity, Allergy, and Autoimmune Diseases
Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc. Chapter 67 Review of the Immune System.
Hypersensitivity Hypersensitivity – Exaggerated immune response that have deleterious effects and causes damage to the individual. Anaphylaxis – an immediate.
Lecture outline Types of hypersensitivity
Principles of Immunology Hypersensitivity and Allergy 4/11/06
Allergy and Hypersensitivity K. J. Goodrum Types of Immune Hypersensitivity Reactions.
Immune System Disorders What is an allergy anyway?
Department of Pathology
Chapter 15 Hypersensitivity Reactions, Allergies Dr. Capers
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Fundamentals of Anatomy & Physiology SIXTH EDITION Frederic H. Martini PowerPoint.
Hypersensitivity immunology. What is hypersensitivity?  the violent reaction of the immune system leading to severe symptoms and even death in sensitised.
Hypersensitivity Reactions:
Hypersensitivity Reactions: Definitions: Hypersensitivity reactions: inflammatory immune responses induced by repeated antigen exposure resulting in host.
The Molecular Basis for Dept of Pathology, Immunology unit
Topics Type III hypersensitivity Type IV hypersensitivity 18-1.
Chapter 15 Hypersensitivity Reaction
Section 2 Hypersensitivity Reactions
The Immune System Part 3. What Could Go Wrong? A. Immune Deficiency Disorder B. Hypersensitivity Disorder C. Autoimmune Disorder D. Immunoproliferative.
18-1 Important terms: Hypersensitivity – immune responses that causes tissue damage Autoimmune disease – immune responses to self-antigens Immunodeficiency.
Allergy and Hypersensitivity Zahaib Quadri MD Department of physiology Dow medical college, DUHS.
PhD. student kefah F.Hasson 2014 Hypersensitivity Reactions type III.
Chapter 4 Immunity, Hypersensitivity, Allergy, and Autoimmune Diseases.
Autoimmunity Immune system has evolved to discriminate between self and non-self or discriminate between safe and dangerous signalsImmune system has evolved.
ALLERGOLOGY The branch of medical science that studies the causes and treatment of allergies.
Genetics, Altered Immune Responses, and Transplantation Chapter 14 Overview Copyright © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc.
Hypersensitivity Reactions. Hypersensitivity reactions: Inflammatory immune responses induced by repeated antigen (allergen) exposure resulting in host.
Type III hypersensitivity (immune complex). Introduction Large amounts of immune complexes can lead to tissue damage, either in local sites or systemically,
Immune Injury Hypersensitivities Autoimmune Disorders.
Hypersensitivity Reactions. Injurious, patologic immune reactions causing tissue injury and disease Excessive or aberrant immune response to: Foreign.
Aims Explain the mechanisms of hypersensitivity reactions. Define anaphylaxis Readings: Abbas & Lichtman, Chapter 11.
IMMUNE SYSTEM Chapter 21.
Food Allergy & Food Intolerance. Allergy an abnormal reaction of the immune system to foreign (not infectious) material, leading to injury to the body.
1 Dr. Amel Eassawi Dr. Abdelrahman Mustafa. HMIM 224 L3: AUTOTOLERANCE 2.
Immunology Unit Department of Pathology College of Medicine King Saud University.
Chapter 15 Hypersensitivity Reactions Mast cell. Although the word “ hypersensitivity ” implies an increased response, the immune response of a hypersensitivity.
Immune System Chapter 43. Introduction to the Immune System An animal must defend itself against unwelcome intruders. An animal must defend itself against.
Type II Cytotoxic hypersensitivity Reaction time is minutes to hours mediated by antibodies of IgM or IgG class and complement Phagocytes and NK cells.
Part B Autoimmune Diseases Part B Autoimmune Diseases Effector mechanisms of autoimmune disease Endocrine glands as special targets.
Principles of Immunology Autoimmunity 4/25/06. Organs Specific Autoimmune Diseases  Hashimoto’s thyroiditis DTH like response to thyroid Ags Ab to thyroglobulin.
Disorders of Immune System - Hypersensitivity Reactions: Immune response to exogenous antigens - Autoimmune diseases: Immune reactions against self antigens.
Immunopathology Dr JG Lawrenson. Immunopathology Hypersensitivity Autoimmunity Immunodeficiency © Dr JG Lawrenson 2001.
Hypersensitive Reactions. Immunopathology Exaggerated immune response may lead to different forms of tissue damage 1) An overactive immune response: produce.
Hypersensitivity reactions: Antibody-mediated (type II) cytotoxic reactions and immune complex (type III) reactions.
1 How we prevent infection. 2 Ch Innate Immunity.
HYPERSENSITIVITY REACTIONS AND AUTOIMMUNITY
TYPE III & IV HYPERSENSITIVITY REACTION 1 Hypersensitivity reaction.
Type I. „immediate” Type II.Type III.Type IV. „late” Antibody mediatedT cell mediated AN OVERVIEW OF HYPERSENSITIVITY REACTIONS.
HYPERSENSITIVITY REACTIONS Innocous materials can cause hypersensitivity in certain individuals unwanted inflammation damaged cells and tissues Non-proper.
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings PowerPoint ® Lecture Slide Presentation prepared by Christine L. Case Microbiology.
Autoimmunity is a destructive immune response against self antigens Autoimmune diseases are hard to stop Severity ranges from minor to lethal.
Type I. „immediate” Type II.Type III.Type IV. „late” Antibody mediatedT cell mediated AN OVERVIEW OF HYPERSENSITIVITY REACTIONS.
Kindt • Goldsby • Osborne
Copyright © 2011 Pearson Education Inc. Lecture prepared by Mindy Miller-Kittrell, University of Tennessee, Knoxville M I C R O B I O L O G Y WITH DISEASES.
Hypersensitivity Cell mediated immunity Lecture by professor. M.Boychenko.
Specific Acquired Immune Response A specific response that is directed only at the invading agent. Two keys words to remember: Specific Memory bio-alive.com.
The immune system gone wrong: Diseases of immunity
Immune Mediated Disorders
Hypersensitivity (also called hypersensitivity reaction)
Type II Directed against cell surface or tissue antigen
Hypersensitivity Ali Al Khader, M.D. Faculty of Medicine
Hypersensitivity Reactions
Cytotoxic Hypersensitivity (Type II)
Cytotoxic Hypersensitivity (Type II)
Types of Hypersensitivity Reactions
Defense and Immunity I. First Lines of Defense A. Mechanical Barriers
Hypersensitivity Ali Al Khader, M.D. Faculty of Medicine
Immunopathology. Immunotherapy and immuno-prophylaxis.
Topics Type III hypersensitivity Type IV hypersensitivity 18-1.
Presentation transcript:

Hypersensitivity Reactions

Injurious, patologic immune reactions causing tissue injury and disease Excessive or aberrant immune response to: Foreign antigens (non-self) - non-infectious (environmental) - infectious Self (autologous) antigens failure of self-tolerance (autoimmunity, autoimmune diseases)

Types of Hypersensitivity Reactions Type I Type II Type III Type IV Antibody mediated T cell mediated

Type II and type III (comparison)

Type II hypersensitivity animation Type II (Antibody-mediated diseases) (Cytotoxic type)

Effector mechanisms

Graves disease

Myasthenia gravis

Antibody-mediated diseases

Type III (immune complex-mediated diseases) Type III hypersensitivity animation

Effector mechanisms

Immune complex diseases

Serum sickness

Therapy Reduction fo inflammation (corticosteroids) Plasmapheresis (reduction of circulating antibodies and immune comoplexes) Anti-CD20-antibodies (reduction of B cell number) Inhibition of auto-antibody production (CD40L antagonists)

Type IV (Delayed-Type Hypersensitivity - DTH) Type IV hypersensitivity animation

Effector mechanisms

T cell-mediated diseases

Clinical manifestation of contact dermatitis

Reduction of inlammtaion (corticosteroids and TNF antagonists) T cell response inhibition (cyclosporin) Antagonists of costimulation Therapy

Feedback: Privacy Policy Feedback
Do Not Sell My Personal Information
About project: SlidePlayer Terms of Service

© 2025 SlidePlayer.com. Inc. All rights reserved.