Chapter 8: Sampling, Standardization & Calibration

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Chapter 8: Sampling, Standardization & Calibration CHE 321: Quantitative Chemical Analysis Dr. Jerome Williams, Ph.D. Saint Leo University

Overview Standardization & Calibration Sensitivity & Detection Limits

Standardization & Calibration Calibration determines relationship between analyte response & analyte concentration. Accomplished using chemical standards.

Standardization & Calibration Comparison with Standards Direct comparison (Colorimeters & Titrations) External Standard Calibration (Least Squares Method)

Figure 8-9 p172

Figure 8-10 p172

Table 8-1 p175

Table 8-2 p177

Table 8-3 p178

Fig 8-9, p.195

Standardization & Calibration Errors in External Standard Calibration Blanks are used to correct for many calibration errors. Ideal blank contains everything except the analyte. Solvent blank or reagent blank more practical.

Standardization & Calibration Minimizing Errors in Analytical Procedures Multivariate Calibration Saturation, Matrix Modification, & Masking Internal Standard Methods Standard Addition Methods

Sensitivity & Detection Limits Be familiar with the following terms Analytical & Calibration Sensitivity Detection Limit Linear Dynamic Range Control Chart (including UCL, LCL) Statistical Control Validation & GLP

Figure 8-14 p187

Figure 8-15 p189

p189

p189

Figure 8-16 p190

Suggested Problems HW Set 7: 8.1, 8.2, 8.3, 8.17, 8.26

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