Welcome to IB 201! Genetics and Evolution

Instructors Teaching Assistants Moni Berg Karen Cavey Casey Funderburk Beth Ruedi Lecture Dr. Kim Hughes (Genetics) Dr. Sydney Cameron (Evolution) Laboratory Dr. Kevin Dixon

Required Texts Selected Chapters from “Essential Genetics”, by Russell, available online “Evolutionary Biology”, by Freeman and Herron Other reading material will be distributed in class or available on the course web site.

How to access the chapters of the Genetics text online Go to Once there you should register as a student. Enter your code to register and create a login and password. Once you are logged in select IB 201 under the courses option. Select “Biology Chapters” from the side menu. Scroll down until you get to “Genetics Appendix”. 6 chapters from the Genetics text (by Russell). You can download them and either view them on your computer or print them out.

Course Web Site Class schedule Assigned readings Homework assignments Lecture notes Powerpoint slides Recommended problens

Course Pre-requisites IB 150: Organismal and Evolutionary Biology MCB 150: Molecular and Cellular Basis of Life Review material available on the course web site: Basic Mendelian and Molecular Genetics

Grading Lecture: 70% of grade; Laboratory: 30% Lecture: 700 points total: Two Midterms: 75 points each Final Exam (cumulative): 100 points Six Homework assignments: 75 pts ea Online multiple-choice assignments: access them from the course web site.

Extra Credit Questions at beginning of class Based on reading assignment Answer due before class starts 2 pts each class (one-half letter grade)

Course Policies NO MAKEUP EXAMS HW assignments posted on the course web site, due before 9:00 am on due date. No extensions Final: 1:30-4:30 pm Friday, May 6, in this room

Course Policies NO MAKEUP EXAMS HW assignments posted on the course web site, due before 9:00 am on due date. No extensions Final: 1:30-4:30 pm Friday, May 6, in this room

How to succeed in this course  Come to class!  Read the assigned material before class  Download lecture notes before class.  Bring a calculator and scrap paper to class.  Do recommended problems: you will see them again!  Participate in class discussion

Don’t  Furiously take notes during class  Put off the homework until the last minute  Put off doing recommended problems until just before the exam

IB 201 Genetics and Evolution Part 1 Genetics Dr. Kim Hughes 465B Morrill Hall Office hours: Tu/Th after class or by appointment

Practice Quiz 1. Round-seeded pea was crossed to a wrinkle-seeded pea all the offspring were round. Diagram the cross and predict the ratio of wrinkled to round offspring in the F2 generation. 2. A round-seeded pea is crossed to a wrinkle-seeded pea. Half the offspring are round and half are wrinkled. What are the genotypes of the parents, the round F1 offspring, and the wrinkled F1 offspring? 3. True-breeding yellow, round plants were crossed to true breeding green, wrinkled ones. All F1 offspring are yellow and round. What are the genotypes of the parents and the F1 offspring? What phenotypes, and in what proportions, do you expect in the F2 generation? 4. A red snapdragon is crossed to a white snapdragon and all the offspring are pink. This is an example of what genetic property?

Practice Quiz 5. A woman homozygous for the A allele of the ABO blood group marries a man who is homozygous for the B locus. What is the blood group phenotype of their child? This is an example of what genetic property? 6. What is the most likely mode of inheritance illustrated by this pedigree? 7. The combined probability of two or more mutually exclusive events occurring is the ________ of their individual probabilities. 8. The joint probability of both of two independent events occurring is the _________ of their individual probabilities.

Terms you should know Gene Locus Allele Dominance Recessiveness Wild type Mutation Genotype Phenotype Homozygote Heterozygote Monohybrid Dihybrid Pleiotropy Epistasis Autosome Sex chromosome Hemizygous Pleiotropy Epistasis Haploid Diploid Nuclear DNA Mitochondrial DNA Chloroplast DNA Chromosome Homologous chromosomes Sister chromatids Tetrad Mitosis Meoisis Independent assortment Recombination Crossing over Transcription Translation

Answers 1.P: WW x ww F1: Ww F2: 3/4 round (W-) to 1/4 wrinkled (ww) 2. P: Ww x ww F1: 1/2 Ww (round) and 1/2 ww (wrinkled) 3. P: GG WW x gg ww F1: Gg Ww F2: 9/16 yellow, round (G- W-); 3/16 yellow, wrinkled (G- ww); 3/16 green, round (gg W-); 1/4 green, wrinkled (gg ww) 4.Incomplete dominance 5.AB; Codominance 6.X-linked recessive 7.Sum (this is the “sum rule” or the “addition rule” of probability 8.Product (this is the “product rule of probability)

If you found these questions easy You’re prepared to start this class If these questions were not easy You should attend the review session and study review material Review session: Today, 5 pm, 140 Burrill Hall