The Osteoinductivity of Silicate-Substituted Calcium Phosphate by Melanie J. Coathup, Sorousheh Samizadeh, Yvette S. Fang, Thomas Buckland, Karin A. Hing,

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The Osteoinductivity of Silicate-Substituted Calcium Phosphate by Melanie J. Coathup, Sorousheh Samizadeh, Yvette S. Fang, Thomas Buckland, Karin A. Hing, and Gordon W. Blunn J Bone Joint Surg Am Volume 93(23): December 7, 2011 ©2011 by The Journal of Bone and Joint Surgery, Inc.

Scanning electron micrographs comparing bone formation within silicate-substituted calcium phosphate (SiCaP) specimens (Fig. 1-A) and stoichiometric calcium phosphate (CaP) specimens (Fig. 1-B). Melanie J. Coathup et al. J Bone Joint Surg Am 2011;93: ©2011 by The Journal of Bone and Joint Surgery, Inc.

Figs. 2-A, 2-B, and 2-C Photomicrographs showing bone growth within micropores in silicate- substituted calcium phosphate (SiCaP) struts <5 μm in size. Melanie J. Coathup et al. J Bone Joint Surg Am 2011;93: ©2011 by The Journal of Bone and Joint Surgery, Inc.

Fig. 3-A Scanning electron micrograph showing a small area of bone within a micropore in the silicate-substituted calcium phosphate (SiCaP) group. Melanie J. Coathup et al. J Bone Joint Surg Am 2011;93: ©2011 by The Journal of Bone and Joint Surgery, Inc.

Light microscopy image showing osteoblast-like cells on the surface of silicate-substituted calcium phosphate granules. Melanie J. Coathup et al. J Bone Joint Surg Am 2011;93: ©2011 by The Journal of Bone and Joint Surgery, Inc.

Photomicrograph showing bone formation occurring on the SiCaP-30 surface through an intramembranous ossification process. Melanie J. Coathup et al. J Bone Joint Surg Am 2011;93: ©2011 by The Journal of Bone and Joint Surgery, Inc.

Figs. 6-A and 6-B Light microscopy images showing the development of bone on the concave surface of a pore in a silicate-substituted calcium phosphate specimen. Melanie J. Coathup et al. J Bone Joint Surg Am 2011;93: ©2011 by The Journal of Bone and Joint Surgery, Inc.

Photomicrograph showing osteoclast-like cells on the implant surface that are packed with silicate-substituted calcium phosphate particles. Melanie J. Coathup et al. J Bone Joint Surg Am 2011;93: ©2011 by The Journal of Bone and Joint Surgery, Inc.