Pathogenesis of non-alcoholic fatty liver disease by J. K. Dowman, J.W. Tomlinson, and P.N. Newsome QJM Volume ():hcp158 November 13, 2009 © 2009 The Author(s)‏

Slides:

Advertisements

Similar presentations

Non-alcoholic fatty liver disease and when to refer abnormal LFTs

Advertisements

Clinical Model for NASH and Advanced Fibrosis in Adult Patients With Diabetes and NAFLD: Guidelines for Referral in NAFLD Featured Article: Jessica Bazick,

 Fatty liver disease can range from fatty liver alone (steatosis) to fatty liver associated with inflammation (steatohepatitis). This condition can occur.

Non-alcoholic Fatty Liver Disease

Osteoporosis therapy: an example of putting evidence- based medicine into clinical practice by D.J. Hosking, P. Geusens, and R. Rizzoli QJM Volume 98(6):

Uncovering the basis of a severe degree of acidemia in a patient with diabetic ketoacidosis by M. Gowrishankar, A.P.C.P. Carlotti, C. St George-Hyslop,

Emergencies in hereditary haemorrhagic telangiectasia by M. Gallitelli, G. Pasculli, T. Fiore, A. Carella, and C. Sabbà QJM Volume 99(1):15-22 December.

The rising number of underfoot accidents after the menopause causes both fractures and non ‐ fracture injuries by J.C. Davies, D.P. Manning, G.J. Kemp,

Recent advances in the monitoring and management of diabetic ketoacidosis by T.M. Wallace, and D.R. Matthews QJM Volume 97(12): November 29, 2004.

Cancer cachexia by J.N. Gordon, S.R. Green, and P.M. Goggin QJM Volume 98(11): October 17, 2005 © The Author Published by Oxford University.

The effect of cholecalciferol (vitamin D 3 ) on the risk of fall and fracture: a meta-analysis by C. Jackson, S. Gaugris, S.S. Sen, and D. Hosking QJM.

Hepatic Steatosis Chen-Yu Wang

Pasi Erkkilä and Akseli Koskela

What Is the Disease of Obesity?

Figure 1 Proposed risk stratification for patients with NAFLD

Nutritional therapy for nonalcoholic fatty liver disease

Hierarchical clustering of DEGs in Shp−/− mice, chronic hepatitis C cirrhosis, and NASH. A: unsupervised hierarchical clustering of genes common to the.

Fatty liver. In some cases, the fatty change seen in alcoholics will involve the entire liver (i.e., diffuse fatty liver). Fatty liver can also occur with.

Pathophysiological alterations leading to neuronal injury during bacterial meningitis. BBB, blood-brain barrier; CBV, cerebral blood volume. (Redrawn,

Proposed mechanism for the pathogenesis of pulmonary fibrosis

Ectopic fat and cardiometabolic and vascular risk

Bin Gao, Hidekazu Tsukamoto Gastroenterology

MRI and MRE for non-invasive quantitative assessment of hepatic steatosis and fibrosis in NAFLD and NASH: Clinical trials to clinical practice Parambir.

Volume 148, Issue 4, Pages (April 2015)

From Fat to Inflammation

More Than Meets the Eye: Identifying Who Is at Risk for NASH

PNPLA3 gene in liver diseases

Cláudia Fagundes, MD, Pere Ginès, MD, PhD

Volume 143, Issue 5, Pages (November 2012)

Figure 2 Proinflammatory mechanisms in CKD

Les Lang Gastroenterology Volume 133, Issue 1, (July 2007)

Les Lang Gastroenterology Volume 133, Issue 1, (July 2007)

An Unusual Cause of Abdominal Pain in Sickle Cell Disease

Genetic sequence analysis of inherited bleeding diseases

Leptin, obesity, and liver disease

Genetics and Genomics in the Practice of Medicine

Hepatitis B and C virus-related carcinogenesis

Figure 4 Effects of irisin on glucose homeostasis

Nat. Rev. Nephrol. doi: /nrneph

Volume 149, Issue 2, Pages (August 2015)

Nat. Rev. Cardiol. doi: /nrcardio

Stephen A. Harrison, MD, FACP Clinical Gastroenterology and Hepatology

Figure 2 Organ crosstalk in the pathophysiology

Volume 155, Issue 1, Pages (July 2018)

TLL1 rs Increases the Risk of Fibrosis Progression in Caucasian Patients With Chronic Hepatitis C Miya John, Mayada Metwally Gastroenterology

Michael Downes, Christopher Liddle Cell Metabolism

Long-Term Outcomes of Nonalcoholic Fatty Liver Disease: From Nonalcoholic Steatohepatitis to Nonalcoholic Steatofibrosis Zobair M. Younossi Clinical.

Abstracts from Around the World

Acute-on chronic liver failure

Figure 6 Possible therapeutic targets to decrease hepatic steatosis

Volume 54, Issue 5, Pages (May 2011)

Volume 61, Issue 1, Pages S69-S78 (November 2014)

Noninvasive Assessment of Nonalcoholic Fatty Liver Disease in Obese or Overweight Patients Sven M.A. Francque, An Verrijken, Ilse Mertens, Guy Hubens,

Michael Charlton Clinical Gastroenterology and Hepatology

When the journey from obesity to cirrhosis takes an early start

Figure 1 The current model of the pathogenesis of SLE

Sedentary time was higher in non-alcoholic fatty liver disease (NAFLD) than healthy controls with fewer sedentary to active transitions (data reported.

Association between Nonalcoholic Fatty Liver Disease at CT and Coronary Microvascular Dysfunction at Myocardial Perfusion PET/CT Coronary microvascular.

NAFLD (nonalcoholic fatty liver disease), CVD, and type 2 diabetes: Details of the study design Targher G et al. Diabetes Care 2007;30:

Hepatitis B and C virus-related carcinogenesis

AGA technical review on nonalcoholic fatty liver disease

Statin Use and Risk of Cirrhosis and Related Complications in Patients With Chronic Liver Diseases: A Systematic Review and Meta-analysis Rebecca G.

Figure 1 NAFLD pathogenesis

Brandon J. Thomas, Stephen T. Smale Immunity

Pathogenesis of cholestatic hepatitis C

Trunk Fat as a Determinant of Liver Disease

Achieving Fairness in Access to Kidney Transplant: A Work in Progress

The metabolomic window into hepatobiliary disease

Volume 135, Issue 6, Pages (December 2008)

Fig. 4: Schematic, initial diagnostic algorithm for a patient presenting with mild aminotransferase abnormality. Fig. 4: Schematic, initial diagnostic.

Presentation transcript:

Pathogenesis of non-alcoholic fatty liver disease by J. K. Dowman, J.W. Tomlinson, and P.N. Newsome QJM Volume ():hcp158 November 13, 2009 © 2009 The Author(s)‏

J. K. Dowman et al. QJM 2009;qjmed.hcp158 © 2009 The Author(s)‏

J. K. Dowman et al. QJM 2009;qjmed.hcp158 © 2009 The Author(s)‏

Mechanisms of hepatic fat accumulation. J. K. Dowman et al. QJM 2009;qjmed.hcp158 © 2009 The Author(s)‏

Proposed pathogenesis of NASH. The likelihood of progression to advanced NASH/cirrhosis results from a complex interplay between genetic predisposition and the mechanisms described earlier. J. K. Dowman et al. QJM 2009;qjmed.hcp158 © 2009 The Author(s)‏