Chapter 6 Outline 6.1 The Study of Genetics in Humans Is Constrained by Special Features of Human Biology and Culture, 135 6.2 Geneticists Often Use Pedigrees.

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Chapter 6 Outline 6.1 The Study of Genetics in Humans Is Constrained by Special Features of Human Biology and Culture, Geneticists Often Use Pedigrees to Study the Inheritance of Characteristics in Humans, Analysis of Pedigrees Requires Recognizing Patterns Associated with Different Modes of Inheritance, The Study of Twins Can Be Used to Assess the Importance of Genes and Environment on Variation in a Trait, 142

Chapter 6 Outline 6.5 Adoption Studies Are Another Technique for Examining the Effects of Genes and Environment on Variation in Traits, Genetic Counseling Provides Information to Those Concerned about Genetic Diseases and Traits, Genetic Testing Provides Information about the Potential for Inheriting or Developing a Genetic Condition, Comparison of Human and Chimpanzee Genomes Is Helping to Reveal Genes That Make Humans Unique, 151

6.1 The Study of Genetics in Humans Is Constrained by Special Features of Human Biology and Culture Special features: Controlled mating is not possible Long generation time Small family size

Pedigree: pictorial representation of a family history, a family tree that outlines the inheritance of one or more characteristics Proband: the person with whom the pedigree is initiated 6.2 Geneticists Often Use Pedigrees to Study the Inheritance of Characteristics in Humans

Autosome Recessive Traits 6.3 Analysis of Pedigrees Requires Recognizing Patterns Associated with Different Modes of Inheritance

Autosomal Dominant Traits 6.3 Analysis of Pedigrees Requires Recognizing Patterns Associated with Different Modes of Inheritance

X-Linked Recessive Traits 6.3 Analysis of Pedigrees Requires Recognizing Patterns Associated with Different Modes of Inheritance

X-Linked Dominant Traits 6.3 Analysis of Pedigrees Requires Recognizing Patterns Associated with Different Modes of Inheritance

Y-Linked Traits 6.3 Analysis of Pedigrees Requires Recognizing Patterns Associated with Different Modes of Inheritance

6.4 The Study of Twins Can Be Used to Assess the Importance of Genes and Environment on Variation in a Trait Dizygotic twins = non-identical twins Monozygotic twins = identical twins Concordant trait: the trait shared by both members of a twin pair Concordance: the percentage of twin pairs that are concordant for a trait

6.4 The Study of Twins Can Be Used to Assess the Importance of Genes and Environment on Variation in a Trait Twin Studies and Obesity

6.6 Genetic Counseling Provides Information to Those Concerned about Genetic Diseases and Traits Genetic counseling: provides information related to hereditory conditions

6.8 Comparison of Human and Chimpanzee Genomes Is Helping to Reveal Genes That Make Humans Unique Microcephalin 1 to microcephalin 6 regulates human brain size. FOXP 2 regulates human speech.