Review of Anticoagulants, Thrombolytics and Anti-platelet Drugs 3 November :19 AM

Abciximab Antiplatelet Anti-GPIIb/IIIa receptor antibody

Adalimumab TNF inhibitor Anti-TNF antibody Used in rheumatoid arthritis

Allopurinol Antigout Antineoplastic (supporting agent) Folic acid analogue Xanthine oxidase inhibitor

Aminocaproic acid (EACA) Procoagulant Inhibitor of plasminogen activation (decreases fibrinolysis)

Anistreplase Thrombolytic Streptokinase + plasminogen

Aprotinin Procoagulant Fibrinolytic inhibitor Serine protease inhibitor (“serpin”) Streptokinase inhibitor

Argatroban Anticoagulant Direct thrombin inhibitor

Aspirin (Acetylsalicylic acid, ASA) NSAID (acetylsalicylate) Analgesic, Anti-inflammatory Antipyretic, Antiplatelet Irreversible cyclooxygenase inhibitor

Atorvastatin Antihyperlipidemic HMG-CoA reductase inhibitor

Auranofin Disease modifying anti-rheumatic drug (DMARD) Gold salt Oral

Aurothioglucose Disease modifying anti-rheumatic drug (DMARD) Gold salt Parenteral

Balsalazide NSAID (salicylate) Treatment of IBD

Beclomethasone Adrenocorticosteroid Glucocorticoid Anti-inflammatory steroid Inhaled

Betamethasone Adrenocorticosteroid Glucocorticoid Anti-inflammatory steroid Not by inhalation

Bivalirudin Anticoagulant Direct thrombin inhibitor

Bradykinin Inflammatory mediator Plasma, hypotension, pain

Budesonide Adrenocorticosteroid Glucocorticoid Anti-inflammatory steroid Inhaled OR treatment of IBD

C3a, C5a Inflammatory mediators Anaphylatoxins Low molecular weight complement cleavage products

Celecoxib NSAID Anti-inflammatory Cyclooxygenase 2 (COX-2) inhibitor

Cholestyramine Antihyperlipidemic Bile acid binding resin (BABR)

Clofibrate Antihyperlipidemic Lipoprotein lipase activator

Clopidogrel Antiplatelet ADP receptor antagonist

Colchicine Antigout only Anti-inflammatory Microtubule inhibitor

Colestipol Antihyperlipidemic Bile acid binding resin (BABR)

Cortisol (Hydrocortisone) Adrenocorticosteroid Glucocorticoid Anti-inflammatory steroid

Cromolyn sodium Mast cell stabilizer Inhibits release of mast cell mediators Used prophylactically in asthma

Dalteparin Anticoagulant LMW Heparin ATIII activator

Dexamethasone Adrenocorticosteroid Glucocorticoid Antineoplastic Antiemetic Anti-inflammatory steroid Not by inhalation

Diflunisal NSAID Analgesic, Anti-inflammatory Antipyretic Cyclooxygenase inhibitor

Dipyridamole Antiplatelet Phosphodiesterase inhibitor (increases cAMP)

Drotrecogin alfa (Activated Protein C) Anticoagulant Many actions Treatment for septic shock

Enoxaparin Anticoagulant LMW Heparin ATIII activator

Eptifibatide Antiplatelet GPIIb/IIIa antagonist

Erythropoietin (EPO) Cytokine Primary regulator of RBC synthesis

Etanercept TNF inhibitor Tumor necrosis factor receptor + F c portion of IgG Used in rheumatoid arthritis

Ezitimibe Antihyperlipidemic Cholesterol absorption inhibitor

Fenofibrate Antihyperlipidemic Lipoprotein lipase activator

Flunisolide Adrenocorticosteroid Glucocorticoid Anti-inflammatory steroid Inhaled

Fluticasone Adrenocorticosteroid Glucocorticoid Anti-inflammatory steroid Inhaled

Fluvastatin Antihyperlipidemic HMG-CoA Reductase Inhibitor

Gemfibrozil Antihyperlipidemic Lipoprotein lipase activator

Gold salts Disease modifying anti-rheumatic drugs (DMARD) auranofin, aurothioglucose

Granulocyte-Colony Stimulating Factor (G-CSF) Cytokine Granulocyte synthesis stimulator

Granulocyte/Monocyte-Colony Stimulating Factor (GM-CSF) Cytokine WBC (granulocytes and monocyte) synthesis stimulator

Heparin Anticoagulant ATIII activator

Hirudin Anticoagulant Direct thrombin inhibitor (DTI)

Histamine Inflammatory mediator Stored in mast cells and basophils

Hydrocortisone Adrenocorticosteroid Glucocorticoid Anti-inflammatory steroid

Hydroxychloroquine Disease modifying anti-rheumatic drug (DMARD)

4-Hydroxycoumarin Oral anticoagulant Vitamin K synthesis inhibitor

Ibuprofen NSAID Analgesic, Anti-inflammatory Antipyretic Reversible cyclooxygenase inhibitor

Indomethacin NSAID Analgesic, Anti-inflammatory, Antipyretic Cyclooxygenase inhibitor Tocolytic Uterine relaxant

Infliximab TNF inhibitor Anti-TNF monoclonal antibody Treatment of IBD

Interferon alpha Antiviral for hepatitis Antineoplastic Cytokine Anti-angiogenesis

Interleukin 2 Cytokine Antineoplastic

Interleukin 11 Cytokine Antineoplastic (supporting agent)

Kallidin Inflammatory mediator Plasma, hypotension, pain

Ketoprofen NSAID Analgesic, Anti-inflammatory, Antipyretic Cyclooxygenase inhibitor

Lepirudin Anticoagulant Direct thrombin inhibitor (DTI)

Leukotriene B 4 (LTB 4 ) Inflammatory mediator Lipoxygenase product of arachidonate metabolism Chemotactic

Leukotrienes C 4, D 4, E 4 (LTC 4, LTD 4, LTE 4 ) Inflammatory mediators Cysteinyl leukotrienes Peptidyl leukotrienes SRS-A Lipoxygenase products of arachidonate metabolism

Lovastatin Antihyperlipidemic HMG-CoA reductase inhibitor

Meclofenamate NSAID Analgesic, Anti-inflammatory, Antipyretic Cyclooxygenase inhibitor

Mesalamine (5-ASA) NSAID (salicylate) Treatment of IBD

Methylprednisolone Adrenocorticosteroid Glucocorticoid Anti-inflammatory steroid Not by inhalation

Montelukast Leukotriene inhibitor LTR1 and LTD4 antagonist Asthma treatment

Naproxen NSAID Analgesic, Anti-inflammatory, Antipyretic Cyclooxygenase inhibitor

Nedocromil Mast cell stabilizer Inhibits release of mast cell mediators Used prophylactically in asthma

Nicotinic acid Antihyperlipidemic Inhibition of VLDL secretion (?)

Non-steroidal Anti-inflammatory Drugs (NSAIDs) Analgesic, Anti-inflammatory, Antipyretic Cyclooxygenase inhibitors

Olsalazine NSAID (salicylate) Treatment of IBD

Phytonadione Vitamin K Warfarin antagonist

Piroxicam NSAID Analgesic, Anti-inflammatory, Antipyretic Cyclooxygenase inhibitor

Platelet Activating Factor (PAF) Inflammatory mediator Lipid Hypotensive

Pravastatin Antihyperlipidemic HMG-CoA reductase inhibitor

Prednisone Adrenocorticosteroid Glucocorticoid Antineoplastic Anti-inflammatory Not by inhalation

Probenecid Uricosuric Adjunct in penicillin therapy

Probucol Antihyperlipidemic LDL oxidation inhibitor

Prostaglandin E 2 (PGE 2 ) Dinoprostone (Dinoprost) Oxytocic prostaglandin Inflammatory mediator Cyclooxygenase product of arachidonate metabolism Uterine stimulant Cervical ripener

Prostaglandin F 2 (PGF 2 ) Inflammatory mediator Cyclooxygenase product of arachidonate metabolism

Prostaglandin I 2 (PGI 2 ) Inflammatory mediator Inhibits platelet aggregation Cyclooxygenase product of arachidonate metabolism Prostacyclin

Protamine Sulfate Heparin antagonist

Rofecoxib NSAID Anti-inflammatory Cyclooxygenase 2 (COX-2) inhibitor

Simvastatin Antihyperlipidemic HMG-CoA reductase inhibitor

Streptokinase Thrombolytic

Rofecoxib NSAID Anti-inflammatory Cyclooxygenase 2 (COX-2) inhibitor

Sulfasalazine Disease modifying anti-rheumatic drug (DMARD) Metabolized to sulfonamide + salicylate (NSAID) Treatment of IBD

Sulfinpyrazone Uricosuric Anti-gout

Sulindac NSAID Analgesic, Anti-inflammatory, Antipyretic Cyclooxygenase inhibitor

Thrombopoietin Cytokine Platelet synthesis stimulator

Thromboxane A 2 (TXA 2 ) Autacoid Promotes platelet aggregation Cyclooxygenase product of arachidonate metabolism

Ticlopidine Antiplatelet ADP receptor antagonist

Tissue plasminogen activators Thrombolytics alteplase, reteplase, tenecteplase

Triamcinolone Adrenocorticosteroid Glucocorticoid Anti-inflammatory steroid Inhaled

Tumor necrosis factor  Cytokine Antineoplastic

Urokinase Thrombolytic

Warfarin Anticoagulant Vitamin K synthesis inhibitor

Zafirlukast Leukotriene inhibitor LTR 1 and LTD 4 antagonist Asthma treatment

Zileuton Leukotriene inhibitor 5-lipoxygenase inhibitor Used in asthma