Positioning Products to Customer in the Target Markets

HPLC used around the world in industrial, research and educational settings Steady growth in installed conventional HPLC and Semi-Prep markets Keep pace with the market needs Why a New Integrated HPLC System?

Analytical BenefitFeatures Expected performanceState of play with specs equivalent or better than waters/Agilent Viable Data SolutionClient server, compliant and fully featured with improved ease of use Vendor supportConsumables, service training, support world wide and at a consistently high level Semi Prep to Prep VersatilityExtended detection, materials and flow range via options ReliabilityNew fraction collector and advanced control of collection Easy scale-upFully automated scale-up through Scale-Up Module and Galaxie Advantages of Integrated Analytical and Prep LC System

Constitutes one quarter of HPLC demand for HPLC Independent testing labs, government bodies, industry effluent testing labs Driven by low detection limits, regulatory compliance and productivity Environmental Industry

Trace organic pollutants in drinking water, ground and surface water, effluents, toxic wastes, soils and seawater PAH, PCB and so on Controlled by regulatory bodies such as EPA, DIN and so on Common Industry Applications

Performance – sensitivity and precision Data compliance and features – for regulated methods Improved reliability and low operating costs – for higher throughput and lower downtime What Do Varian Offer This Industry?

Waters and Agilent have the largest share of the market worldwide Shimadzu tends to be strong in Asia Key Competitors

Gradient pumps with degasser Autosampler Variable UV, diode array and fluorescence detectors Column oven Environmental Systems Requirements

PPS Water Authority, Korea Institute Sea Research (CNR), Italy Zhuhai Water Supply Co., China Gewasser und Bodenschutz, Switzerland Sierra Environmental Monitoring, USA Ministry of Environment & Energy, Canada Heritage Labs, USA Water Eco Science, Australia Pennsylvania American Water, USA Korea Water Resources Corp., Korea Department of Underground Water, Thailand Common Varian Customers in this Market Segment

Typically QA/QC or environmental monitoring application Instruments tend to be dedicated to an application such as: Environmental effluent monitoring Production of raw materials, purity analysis Dissolved materials in organics solvents etc. Driven by performance, price, reliability Chemical and Petrochemical Market

Waters are particularly strong Agilent and Shimadzu Dionex Competitors In Petrochemical Industry

Isocratic or gradient pumps Autosampler for improved productivity UV detectors with RI and ELSD detectors the most relevant detectors What Type of LC System is Important?

Ricca Chemicals, USA Poco Graphite, USA Union of German Cement Factories, Germany Merck, France Ciba Specialty Chemicals, Switzerland Santoku Chemical Industries Co., Japan Existing Varian Petrochemical Customers

Analysis of food and soils Common analyses include crops, soils, feed, fertiliser Typical target substances include sugars, vitamins, organic acids and trace contaminants Industry is driven by price/cost benefit, ease of use, performance and robustness with challenging matrices Agriculture And Food

Gradient pumps Autosamplers increase productivity UV and PDA detectors most common with ELSD and RI also relevant Common Varian customers: Agriquem, Spain Forschungsanstalt Agriculture, Germany University for Agriculture Science, Germany Pepsi (JVA), Ireland Ag Labs (Agmin Chelates), Australia University of Giessen, Germany What Type Of LC System Is Important?

Varied applications – research, environmental, food and beverage, biological Wide variety of laboratories, medical, forensic, life science, university consulting and research labs Driven by: performance (teaching to research), price (grants), reliability Most vendors offer low cost offerings Government and Academic

Modular systems popular Grdient pumps degassers Cooled autosamplers PDA detectors, Fluorescence and ELSD relevant Existing Varian customers MultiLab (State Veterinary Inst.), Liechtenstein University of Melbourne, Australia Max Planck Institut Fuer, Germany State Agency for Standardization & Metrology, Bulgaria University of West Virginia, USA University of Bordeaux, France What Type of LC System is Important?

Most visible conventional HPLC and Prep LC market Small drug companies major users of LC Common applications include: –impurity analysis, –R and D, –cleaning validation, –dissolution testing –discovery and medicinal chemistry analysis purification Pharmaceuticals Market

Performance – sensitivity and precision Data – compliance (auditing and processing) Reliability of instrument Service support, response times Waters and Agilent dominant in this market with software a major factor in many accounts Customer Drivers

Integrated system Gradient pump with degasser Autosampler PDA with column oven Galaxie compliance with IMS, IQ/OQ and CFR compliance Existing Varian customers Pfizer, USA GSK, UK Novartis, Switzerland Varian Offerings to This Market

With the new integrated HPLC system Varian brings reliability, flexibility and performance to the market Can customise systems from conventional to prep Able to have fully integrated hyphenated IRD Can offer one solution to the customer across a range of instrumentation Summary