Food Advisory Committee Meeting Risk Ranking and Risk Prioritization Chemical Contaminants September 29-30, 2014 Nega Beru, Ph.D. Director, Office of Food Safety FDA/Center for Food Safety and Applied Nutrition

Charge to the FAC The FAC is requested to provide FDA input into the development of the characteristics for data collection and risk ranking/prioritization models. The characteristics would be useful in framing the fundamental elements needed to design or evaluate these programs 2

Questions to the FAC What factors, considerations or criteria need to be considered when selecting which food/contaminant pair to sample and test? In the development of models to identify and rank priorities, what factors/criteria need to be considered when “aggregating” or binning foods? Chemical contaminants? 3

Questions to the FAC When using a risk scoring process, what factors/criteria should be considered in deciding where to draw the line – higher vs lower risk? What factors should be considered when establishing the frequency and duration of testing certain chemical compounds? What factors should be considered in deciding to continue vs end testing? 4

Questions for the FAC What factors should be considered where (geographic location or farm to fork food supply continuum) samples should be taken for testing? 5

FDA Compliance Programs Pesticides and industrial chemicals in domestic and imported foods Toxic elements in imported and domestic food and foodware Mycotoxins in domestic and imported foods Chemotherapeutics in seafood 6

Other Surveillance Programs FDA Total Diet Study –Ongoing program surveillance program for various contaminants and nutrients in foods USDA/FSIS National Residue Program –Current focus on veterinary drugs and pesticides in meat, poultry and egg products – plan to expand program to other chemical hazards 7

Models Model developed for determining the most significant foodborne contaminants – FSMA Section 104: Performance Standards High risk foods model – FSMA Section 204: designation of high risk foods Logit model to rank chemicals and group in “bins” 8