Use of Docetaxel based Chemotherapy for Castrate Resistant Prostate Cancer at LASUTH Ikeja Lagos Olufunmilade Akin Omisanjo.

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Use of Docetaxel based Chemotherapy for Castrate Resistant Prostate Cancer at LASUTH Ikeja Lagos Olufunmilade Akin Omisanjo

Background Burden of CAP No widespread screening in Nigeria Late presentation Inevitable progression to CRPC

Background II Challenges with CRPC in Nigeria -different criteria - available treatment options - costs - “physician apathy “ Dearth of Medical/Radiation Oncologists Limited documented experience

Objectives To describe our initial experience with the use of Docetaxel based Chemotherapy in the treatment of CRPC

Materials and Method Patients with CRPC - Steady rise in PSA - Post Ochidectomy - Antiandrogen Treatment - Antiandrogen Withdrawal & Substitution - Testosterone levels in 5 patients - Karnofsky Index 15 month period ( Jan 2013 – March 2014 )

Results 8 patients Mean age : 70.4years ( 65 – 76yrs) Mean PSA pre-commencement of Chemotherapy : 553.1ng/ml ( )

Results II 3 weekly dose : 75mg/m patients Weekly dose : 30mg/m patients Preparation - FBC - E&U,Cr - LFTs - ECG

Results III Drug administration by urologists in all cases 7 patients completed chemotherapy - 5 patients : 6 courses - 2 patients : 10 courses Discontinued in 1 patient

Results III Mean drop in PSA : 67.9% Mean follow up period : 10months ( 4- 18mths)

Results IV Clinical Improvement - analgesia requirements - paraplegia Mortality - 1 cancer related death - 1 non-cancer related death 6 alive - 4 patients up to 12months

Discussion Very high PSA Acceptable Tolerability - Good performance ? Cost effectiveness Study : not about efficacy

Limitations/Recommendations Limited patients Need for multi-centre involvement Chemotherapy for CRPC is possible even in a very busy urology practice More involvement by urologists

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