Littleford Day Inc. Where Processing Ideas become Reality.

Littleford CB High Speed Processor: High Shear DensificationZone Mixing & PredensificationZone DinamicallyBalanced High Speed Shaft. Charging Zone Zone Tangential Liquid Lances on Bottom- Top, Optional Heating/Cooling Jacket (Top & Bottom Shell) Pneumatic Control of Discharge Gate ChargeChute Double Row RowSphericalBearings Throughput (Lbs/Hr) Throughput (Lbs/Hr) Model No. Minimum Maximum CB ,500 CB-50 5,400 27,000 CB-60 9,900 49,000 CB-75 19,000 95,000 CB , ,000 Densification through addition of high shear input rates. Ideal for the densification of several powders. Typical Ideal for the densification of several powders. Typical retention time of common products is 15 to 20 seconds. During that retention time of common products is 15 to 20 seconds. During that time the product is subjected to intense mechanical shear, causing time the product is subjected to intense mechanical shear, causing the fragile spray dried granules to break up and densify. Increases the fragile spray dried granules to break up and densify. Increases in product density of up to 50% in product density of up to 50% If further densification is required, If further densification is required, product is then transferred to a KM product is then transferred to a KM series continuous mixer, delivering series continuous mixer, delivering up to 100% density increase. up to 100% density increase. To an optional KM Continuous Mixer, for up to 100% Densification Littleford Day Inc.

The “Fluidized Bed” Operation for Mixing & Drying: Mixing elements are designed to force the product into appro- priate components of axial & radial motion. The unique mixing action of the FKM series mixers is accomplished by a horizontal shaft which revolves at a high rate of speed rapidly projecting and hurling the mix materials away from the vessel wall into free space, filling the entire vessel. The mixing action causes the materials to crisscross in the direction of the vessel walls and inversely back again, providing a high volume rate of material transfer. The mechanically fluidized bed of particles is the basis of it´s mixing efficiency and accuracy, including mixtures with diverse specific gravities as well as other problems such as liquid incorporation and heat transfer. heat transfer. The unique action created by the movement of the mixing elements produce intense but gentle intermingling of the materials of the mix in a mechanically fluidized bed. Liquid dispersion is done by spraying liquids against fluidized powder, by Top and / or Bottom Mounted Nozzles. INCREASES PRODUCT DENSITY UP TO 50%

Littleford Day Laboratory & Pilot Plant Equipment Littleford Day Laboratory & Pilot Plant Equipment For testing industrial processes in your own manufacturing environment, rent a trial demonstration Mixer or Dryer. Our Trial Demonstration Program allows your company to determine and witness in-house the advantages of the Littleford Day Technology for R & D, product formulation, quality control or direct production scale-up needs. Lab or pilot size units, available for rent or sale are free-standing in design and meet the most stringent requirements Batch Mixing / Processing Ploughshare Units, both for atmospheric / vacuum and Pressure Ops. : From Table-Top 5 & 20 lts units to Pilot 130 lts. Machines Larger sizes are available. FA-3.5 Mixer, Nauta Type,for special mixing, drying requirements. drying requirements Gallons Working Capacity. W-10 High-Intensity vertical mixer, for Compounding & /or other applications re- quiring High-Shear Op. Ten Liters Capacity. Daymax # 10 Dispersers, for high quality dispersions of solids into liquids, such as plastisol, varnish, paint, and other applications. A portion of the rental cost, under this program, will be applied to the purchase of any related Littleford Day Equipment. Experience the Accuracy & Quality of our Technology through Lab & Pilot Size Equipment Littleford Day Statistical Littleford Day Statistical Process Control Technology The most effective way to ensure reproducible product quality from batch to batch is with advanced state-of-the-art instrumentation. Our process control technology allow you to monitor & analyze data throughout the entire pharmaceutical process. Our control technologies manage cycle times, temperatures & other process crite- ria critical to effective product quality control and end point determination. Instrumentation Options Include: A reliable process validation system,including Watt Totalizer & Statistical Process Controls, help meet FDA,3A,USDA & other pharmac- eutical Standards. Programmable Logic Controllers (PLC´s) to help regulate: Vacuum Levels Vacuum Levels Jacket heating & cooling Jacket heating & cooling Chopper timing & duration Chopper timing & duration Control & documentation of Control & documentation of process steps process steps Recording Watt (power) Meters to measure: Total Energy usage,KWh Total Energy usage,KWh Granulation end point Granulation end point Drying stages, from paste Drying stages, from paste to granule to powder. to granule to powder. Power source electrical controls to meet NEMA certified Stds.for your process. your process. Chart recorder to document Temp. Profiles Load cell mounting to detect volatile loss by monitoring change in the loss by monitoring change in the mass weight of your units and its contents. Available Units for the In-Plant Rental Program

Our Installations Minutes away from Greater Cincinnati Airport, Our Lab. Center is fully equipped with all the required machinery for product development: Mixers, Dryers, Reactors, Granulators, Intensive Mixers-Coolers and support equipment such as filtering and vacuum drying systems. Industrial Road (1 Mi) Donaldson Rd. Turfway Rd. Turfway Rd. U.S. 42 U.S. 42 Exit 180 FlorenceUnion GreaterCincinnatiAirport I-275 I-75 To Lexington To Cincinnati 7451 Empire Drive Florence, KY (1/2 Mi) Bring Us Your Toughest Mixing, Drying & Reacting Problems. Technical Center Main Equipment: FM-50 Mixer/Processor Ploughshare FM-130 Mixer/Processor Ploughshare DVT-130 Polyphase Reactor KM-150 Continuous Mixer/Processor M-5 Lab. Mixer & Dryer M-20 Lab. Mixer & Dryer W-180/K-300 PVC Compounder W-10 High Intensity Mixer Daymax 10 Pastes Disperser Daymax 100 Pastes Disperser Mixtruder Sigma Double-Arm Mixer Mogul Tangential Sigma Mixer Cincinnatus Overlapping Sigma Mixer FA-10 Nauta Processor Main Office: Florence, KY. Ph.- (606) Fax: Latin America: Mexico Cy.Ph.- (52-5) Fax: