Fioretti S.; Antik A; Busto S; Bacque MC; Schiavelli R; Domenech A; Vallejos A. Analysis of Kidneys Procured by the Transplant Institute and DGF in Transplant.

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Fioretti S.; Antik A; Busto S; Bacque MC; Schiavelli R; Domenech A; Vallejos A. Analysis of Kidneys Procured by the Transplant Institute and DGF in Transplant Recipients in 2010

Introduction Delayed graft function (DGF) is a quality indicator in organ procurement activity. It is a predictor of graft function as related to donor characteristicsDelayed graft function (DGF) is a quality indicator in organ procurement activity. It is a predictor of graft function as related to donor characteristics Frecuency of DGF: 10-31% ( Lancet 2004; ) Frecuency of DGF: 10-31% ( Lancet 2004; ) DGF is caused by a variety of factors related to the donor and recipient as well as organ procurement techniquesDGF is caused by a variety of factors related to the donor and recipient as well as organ procurement techniques

Objective To analyze the frecuency of DGF and the risk factors associated with donors variables and procurement techniques.To analyze the frecuency of DGF and the risk factors associated with donors variables and procurement techniques.

Materials & Methods Analytic observational multicenter prospective cohort study. Donation procedures were analyzed and followed up for kidney function during one month after trasplantAnalytic observational multicenter prospective cohort study. Donation procedures were analyzed and followed up for kidney function during one month after trasplant Data were collected from National Informatic Registry Trasplant (SINTRA) Data were collected from National Informatic Registry Trasplant (SINTRA) The cohort donors series were collected during one year period (01/01/ /12/2010)The cohort donors series were collected during one year period (01/01/ /12/2010)

The risk factors for DGF analyzed were : age, sex, cause of death, creatinine blood level; hypertension history and cold ischemia time (CIT).The risk factors for DGF analyzed were : age, sex, cause of death, creatinine blood level; hypertension history and cold ischemia time (CIT). Statistical analysis was perfomed using Epi Info with p < 0.05 regarding significance Statistical analysis was perfomed using Epi Info with p < 0.05 regarding significance DGF : need of dialysis during the first week after transplant DGF : need of dialysis during the first week after transplant

160 kidneys 115 (72%) transplanted 106(92%) in follow-up N: (28%) excluded 9 missed follow-up 80 donors CADAVERIC DONORS

DONOR CHARACTERISTICS AVERAGE AGE: 45 SD 16.2 YEARS HYPERTENSION HISTORY N:47(59%)

Creatinine pre ablation 1.12 mg/dl SD 0.61 mg/dl Creatinine pre ablation 1.12 mg/dl SD 0.61 mg/dl COLD ISCHEMIA TIME AND CREATININE PRE ABLATION

RESULTS I N: 106 kidneys

Risk FactorsRRp Hypertension history Age> 50 years SexN/S Cause of deathN/S CreatinineN/S CITN/S RESULTS II

Conclusions The frequency of DGF in Buenos Aires city was 53% The frequency of DGF in Buenos Aires city was 53% The donor age and the hypertension history were the most important DGF predictorsThe donor age and the hypertension history were the most important DGF predictors Continued follow-up kidneys transplant evolution in the following years can help to analyze this quality indicator Continued follow-up kidneys transplant evolution in the following years can help to analyze this quality indicator