WHO Collaborating Centre for Influenza - Australia

Influenza in Australia

Influenza in New Zealand

Monthly distribution of influenza isolates Thailand 2000

Source of Virus Isolates Analysed Jan Jan 2001 Australia Malaysia New Caledonia New Zealand Philippines Singapore South Africa Thailand Taiwan Vietnam

Distribution of Types/Subtypes Jan Jan 2001 A(H3N2) A(H1N1) B 13.8% 59.5% 26.8% 41.1% 36.8% 22.2% 53.1% 26.2% 20.7% 46.3% 41.5% 12.2% Australia New Zealand Other Asia

Influenza A(H1) Analysis (1)

Influenza A(H1) Analysis (2)

Antigenic Analysis of A(H1N1) Isolates Jan - Aug 2000Sept Jan 2001

Influenza A(H1N1) Isolates HA1 Sequence Analysis

Influenza A(H1N1) Isolates NA Sequence Analysis

Influenza A(H3) Analysis ANTISERUM ABCDEFHuman Sera Pool PassageSampleDate REF. Ag SYD/5MOS/10PAN/2007TEHRANSYD/203ULAN A A/SYDNEY/5/ CEK2,E5 B A/MOSCOW/10/99320 > E7 C A/PANAMA/2007/ E7 D A/TEHRAN/14/ X2,E3 E A/SYDNEY/203/ > E4 F A/ULAN/UDE/01/ E6 TEST Ag A/VICTORIA/346/ X,MD1 A/WELLINGTON/13/ MDX,MD1 A/WAIKATO/7/ MDX,MD1 A/WAIKATO/10/ > MEKX,MD1 A/WAIKATO/14/ >2560> MDX,MD1 A/WAIKATO/15/ MEKX,MD1 A/WAIKATO/17/ <20MEKX,MD1 A/STH AUST/101/ MDX,MD A/STH AUST/136/ MDX,MD A/BRISBANE/71/ <20MDX,MD A/BRISBANE/72/ MDX,MD A/BRISBANE/75/ MDX,MD

Antigenic Analysis of A(H3N2) Isolates A/Sydney 5.9% A/Sydney (low) 12.3% A/Moscow 67.8% A/Moscow (low) 14.0% A/Moscow 62.5% A/Moscow (low) 37.5% Jan - Aug 2000Sept Jan 2001

Influenza A(H3N2) Isolates HA1 Sequence Analysis

Influenza A(H3N2) Isolates NA Sequence Analysis

Influenza B Analysis (1)

Influenza B Analysis (2) ANTISERUM PASSAGE ABCDE BEIJ/184YAM/166SICH/379B/JOH/5VIC/504 REF. Ag A B/BEIJING/184/ E10 B B/YAMANASH/166/ E11 C B/SICHUAN/379/ E9 D B/JOHANNESBURG/5/ E5 E B/VICTORIA/504/200080< CEK1E1 TEST Ag B/C’CHURCH/22/ MD B/VICTORIA/114/ MDX,MD B/VICTORIA/107/ MKX,MD B/WELLINGTON/21/ MD B/BRISBANE/30/ MDX,MD B/BRISBANE/38/ MDX,MD B/STH AUST/85/ < MDX,MD B/STH AUST/86/ MDX,MD B/VICTORIA/321/200080< X,MD SAMPLE DATE DATE

B/Shangdong 6.7% B/Beijing 90.5% B/Sichuan 2.9% B/Beijing 60.3% B/Sichuan 39.7% Antigenic Analysis of Type B Isolates Jan - Aug 2000Sept Jan 2001

0246

Influenza B Isolates NA Sequence Analysis

New Cal/20/99 Auck/32/2000 Joh/82/96 Texas/87/2000 Wuhan/292/2000 USA GMTUSA >40Aust GMTAust > Influenza Type A(H1N1) Vaccine Responses - Older Adults 2000

Influenza Type A(H3N2) Vaccine Responses - Older Adults 2000 USA GMTUSA >40Aust GMTAust > Sydney/5/97 Panama/2007/99 Tehran/14/99 Sydney/203/2000 Ulan Ude/1/2000 VBrazil/991/2000 Fujian/40/2000 Hong Kong/1923/2000 Lyon/1242/2000

Influenza Type B Vaccine Responses - Older Adults 2000 Yamanashi/166/98 Joh/5/99 Sichuan/379/99 Auckland/1/2000 Christchurch/2/2000 Zagreb/3578/99 Victoria/504/2000 Alaska/16/2000 Series 9 USA GMTUSA >40Aust GMTAust >