Review of Protein Synthesis

Fig TRANSCRIPTION TRANSLATION DNA mRNA Ribosome Polypeptide (a) Bacterial cell Nuclear envelope TRANSCRIPTION RNA PROCESSING Pre-mRNA DNA mRNA TRANSLATION Ribosome Polypeptide (b) Eukaryotic cell

Fig. 17-3a-1 TRANSCRIPTION DNA mRNA (a) Bacterial cell

Fig. 17-3a-2 (a) Bacterial cell TRANSCRIPTION DNA mRNA TRANSLATION Ribosome Polypeptide

Fig. 17-3b-1 (b) Eukaryotic cell TRANSCRIPTION Nuclear envelope DNA Pre-mRNA

Fig. 17-3b-2 (b) Eukaryotic cell TRANSCRIPTION Nuclear envelope DNA Pre-mRNA RNA PROCESSING mRNA

Fig. 17-3b-3 (b) Eukaryotic cell TRANSCRIPTION Nuclear envelope DNA Pre-mRNA RNA PROCESSING mRNA TRANSLATION Ribosome Polypeptide

Fig DNA molecule Gene 1 Gene 2 Gene 3 DNA template strand TRANSCRIPTION TRANSLATION mRNA Protein Codon Amino acid

Fig Second mRNA base First mRNA base (5 end of codon) Third mRNA base (3 end of codon)

Fig Pre-mRNA mRNA Coding segment Introns cut out and exons spliced together 5 Cap Exon Intron ExonIntron 105 Exon Poly-A tail 5 Cap 5 UTR3 UTR 1 146

Fig RNA transcript (pre-mRNA) Exon 1Exon 2Intron Protein snRNA snRNPs Other proteins 5

Fig RNA transcript (pre-mRNA) Exon 1Exon 2Intron Protein snRNA snRNPs Other proteins 5 5 Spliceosome

Fig RNA transcript (pre-mRNA) Exon 1Exon 2Intron Protein snRNA snRNPs Other proteins 5 5 Spliceosome components Cut-out intron mRNA Exon 1 Exon 2 5

Fig Gene DNA Exon 1Exon 2 Exon 3 Intron Transcription RNA processing Translation Domain 2 Domain 3 Domain 1 Polypeptide

Fig a Wild type 3 DNA template strand mRNA Protein Amino end Stop Carboxyl end A instead of G U instead of C Stop Silent (no effect on amino acid sequence)

Fig b Wild type DNA template strand 3 5 mRNA Protein 5 Amino end Stop Carboxyl end T instead of C A instead of G Stop Missense