Analysis and Management of Microarray Data Previous Workshops –Computer Aided Drug Design –Public Domain Resources in Biology –Application of Computer.

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Presentation transcript:

Analysis and Management of Microarray Data Previous Workshops –Computer Aided Drug Design –Public Domain Resources in Biology –Application of Computer and Interrnet in Bioinformatics –National Workshop on Genomics and Proteomics –Computer Aided Vaccine Design Training Program –On demand for Individuals –South Korea –DOEACC (RCC Chandigarh)

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Analysis and Management of Microarray Data Major Applications Identification of differentially expressed genes in diseased tissues (in presence of drug) Classification of differentially expressed (genes) or clustering/ grouping of genes having similar behaviour in different conditions Use expression profile of known disease to diagnosis and classify of unknown genes

Analysis and Management of Microarray Data Magnitude of Data –Experiments genes in human 320 cell types 2000 compunds 3 times points 2 concentrations 2 replicates –Data Volume 4*10 11 data-points = 1 petaB of Data

Biological question Differentially expressed genes Sample class prediction etc. Scatter Plot PCA Biological verification and interpretation Pre-processing of Patterns Supervised Leannning Experimental design Image analysis Normalization Clustering Differentially Expression R, G 16-bit TIFF files (Rfg, Rbg), (Gfg, Gbg)

Programme  Fundamentals of Microarray (K Ganesan)  Issues in Microarray (Anand K. Bachawat)  Introduction to Statistics (Balvinder Singh)  Statistics using R via Web (G P S Raghava)  Analysis of Microarray Data (G P S Raghava)  Management of Data locally (G P S Raghava)  Database in Molecular Biology(Balvinder Singh)  Repository of Microarray data world-wide (G P S Raghava)