400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 The Lone Star State NotSTAT T Cells ChangesPotpourri.

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Presentation transcript:

The Lone Star State NotSTAT T Cells ChangesPotpourri

The siege on this famous San Antonio mission began February 23, 1836.

What is The Alamo?

This “weird” city also serves as the Capital of Texas.

What is Austin?

This river is the center of the San Antonio RiverWalk.

What is the San Antonio River?

This is the state mammal of Texas.

What is the armadillo?

This is the number of flags the have been flown over Texas.

What is 6? (Spain, France, Mexico, Republic of Texas, U.S. and Confederacy)

It is the essential transcription factor for Th1 cells.

What is T-bet?

It is the essential transcription factor for Treg cells.

What is FOXP3?

It is the essential transcription factor for Th2 cells.

What is GATA-3?

It is the essential transcription factor for Th17 cells.

What is RORγτ?

Defects in STAT3 and FOXP3 cause these two immune deficiencies, respectively.

What is Hyper-IgE and IPEX?

CD28 binds to these CD markers.

What are CD80 and CD86?

When not binding CD28, B7 binds this inhibitory receptor…on this cell.

What is CTLA4 on T cells?

ICOS stands for this.

What is inducible costimulator?

This cytokine is the major stimulus for IgE production.

What is IL4?

This cytokine is the principal eosinophil activator.

What is IL5?

They are the circles deleted from T cells after TCR gene rearrangement.

What are TRECs?

In Ig heavy chain rearrangement, they are the first two regions to rearrange.

What are D and J?

This complex of proteins cleaves DNA between a hepatomer and a coding segment. (hint: Omenn’s)

What is RAG1/RAG2?

This endonuclease opens up the DNA hairpins at the coding ends during rearrangement. (hint: Omenn’s)

What is Artemis?

The mechanism of junctional diversity where N nucleotides are randomly added is mediated by this enzyme.

What is TdT?

This delivers signals from the pre-BCR that mediates survival, proliferation, and maturation beyond pre-B cell stage

What is Btk?

A mutation in this gene results in autoimmune polyendocrine syndrome.

What is AIRE?

Mutations in this gene can lead to selective IgA deficiency or CVID

What is TACI?

These 2 TNF family cytokines are essential for B cell survival and activation. (1 of 2 for points)

What are BAFF and APRIL?

Mutations in any of these 5 things can lead to Hyper-IgM syndrome. (All 5 for points)

What are CD40L, CD40, NEMO, AID, and UNG?