Ectopic Pregnancy studies

Welcome

Introduction ESEP study inclusionESEP study inclusion Follow upFollow up FutureFuture Other projects: METEX studyOther projects: METEX study

MMR EP 0.5/100,000 ( ) “Despite effort, MMR for EP remains static last 20 yrs”

Alert CEMACH recommendation: Guidelines are urgently required for the management “Pain and bleeding in early pregnancy”CEMACH recommendation: Guidelines are urgently required for the management “Pain and bleeding in early pregnancy”. June 28th 2010 Invited session 9: Prevention of maternal death in early pregnancy J. Neilson (UK)

EP Ref: data LMR - Prismant 2005: women had surgery for EP 20% laparotomy only 25 % salpingotomy

Fertility

ESEP study n=450 PTubal EP, normale contra lateral tube ISalpingostomy CSalpingectomy OFertility (time to IUP), repeat EP, PT

ESEP study group

Inclusion, n=

May – June 2009

ECTOPIC THINK ESEP INCLUDE INFORMED CONSENT FINISHED!!! N=450

Your hurdles? ? ? ?

Follow up Serum hCG follow up in both groups until undetectableSerum hCG follow up in both groups until undetectable Questionnaires every 6 monthsQuestionnaires every 6 months –Contraceptive use –Desire for pregnancy –Pregnancy outcome Data base online ( base online (

Dialogue Future esep trialFuture esep trial ESEP

Ref: data LMR - Prismant EP

* 15% verschil IUP, Power 80% alpha 5%, LFU 10%: NNR = EPs per year 151/1500= 5.2 weeks ESEP inclusion completed!!

METEX study n= 72 Ongoing RCT for women with persisting PUL and serum hCG < 2,000 IU/l or women with an EP and serum hCG < 1,500 IU/l Expectant management vs single dose MTX Outcomes:uneventful decline serum hCG (>15%) quality of life, costs, fertility

Inclusions: 32!

Study information Interested in participation? Eligible patient?