Allogeneic Mesenchymal Stem Cells Regenerate Bone in a Critical-Sized Canine Segmental Defect by Treena Livingston Arinzeh, Susan J. Peter, Michael P.

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Presentation transcript:

Allogeneic Mesenchymal Stem Cells Regenerate Bone in a Critical-Sized Canine Segmental Defect by Treena Livingston Arinzeh, Susan J. Peter, Michael P. Archambault, Christian van den Bos, Steve Gordon, Karl Kraus, Alan Smith, and Sudha Kadiyala J Bone Joint Surg Am Volume 85(10): October 1, 2003 ©2003 by The Journal of Bone and Joint Surgery, Inc.

Radiographs of segmental defects treated with allogeneic mesenchymal stem cells loaded onto hydroxyapatite-tricalcium phosphate. Treena Livingston Arinzeh et al. J Bone Joint Surg Am 2003;85: ©2003 by The Journal of Bone and Joint Surgery, Inc.

Radiographs, made at sixteen weeks, of segmental defects that were left untreated, defects treated with cell-free hydroxyapatite-tricalcium phosphate, and defects treated with autologous mesenchymal stem cells (MSC) loaded onto hydroxyapatite-tricalcium pho... Treena Livingston Arinzeh et al. J Bone Joint Surg Am 2003;85: ©2003 by The Journal of Bone and Joint Surgery, Inc.

Photomicrographs of defects treated with allogeneic mesenchymal stem cells loaded onto hydroxyapatite-tricalcium phosphate (C) implants (middle section, hematoxylin and eosin, magnification ×100). Treena Livingston Arinzeh et al. J Bone Joint Surg Am 2003;85: ©2003 by The Journal of Bone and Joint Surgery, Inc.

Photomicrograph, made at eight weeks, of an undecalcified longitudinal section of the entire defect treated with allogeneic mesenchymal stem cells loaded on hydroxyapatite-tricalcium phosphate. Treena Livingston Arinzeh et al. J Bone Joint Surg Am 2003;85: ©2003 by The Journal of Bone and Joint Surgery, Inc.

Photomicrographs, made at sixteen weeks, of undecalcified sections of the defect treated with allogeneic mesenchymal stem cells loaded onto hydroxyapatite-tricalcium phosphate. Treena Livingston Arinzeh et al. J Bone Joint Surg Am 2003;85: ©2003 by The Journal of Bone and Joint Surgery, Inc.