Renaissance Computing Institute: An Overview Lavanya Ramakrishnan, John McGee, Alan Blatecky, Daniel A. Reed Renaissance Computing Institute Duke University North Carolina State University University of North Carolina - Chapel Hill

RENCI: A Catalyst for Innovation A multidisciplinary institute –Duke, UNC, NCState, … Economic development –helping companies and people Inter disciplinary research engagement –biology, humanities, atmospheric sciences, etc Education and outreach –providing hands on experiences –training the next generation work force

It is all about partnerships! TAMU LSU UF UNC, MCNC UAHb

Next Generation CyberInfrastructure Regional vision, national visibility –national and international coupling –standards-based tools and infrastructure Infrastructure to support the science –computing, communications and data management, visualization RENCI/UNC Health Sciences Library R R R R R R R R R R

Research Project Focus Areas Scalable Performance Tools –adaptive resource management –real-time performance and fault indicating data –SvPablo, HAPI, Autopilot, etc. Data Access & Federation –data and metamodels –information visualization Bioinformatics and Biomedical –shared, extensible portal infrastructure –genetics, hapmap simulator, etc Disaster Response –storm surge modeling (SCOOP), –dynamic, adaptive workflows (LEAD)

Integrated Disaster Response SURA Coastal Ocean Observing Program –Integrated Ocean Observing System (IOOS) –event drive storm surge modeling and forecast system NSF ITR Linked Environments for Atmospheric Discovery (LEAD) –an integrated, scalable cyberinfrastructure –performance monitoring and adaptation –fault-tolerance, performability and recovery

BioScience Communities The Carolina Center for Exploratory Genetic Analysis –preliminary planning grant for a national center –develop a prototype informatics infrastructure BioScience Gateways –initial seed funding from UNC-OP –TeraGrid deployment –leverage state-wide investment in bioinformatics and grid –undergraduate education, graduate education, faculty research More on the Bioportal/BioScience Gateway!

Current BioScience Applications Applications –~140 distinct codes Application Suites –EMBOSS European Molecular Biology Open Software Suite –GLIMMER gene identification in microbial DNA –HMMER Hidden Markov Model program for profile-based sequence analysis –NCBI diverse set of tools –PHYLIP PHYLogeny Inference Package for inferring phylogenies Others (incomplete list) –ClustalW, FASTA Standard bioinformatics databases –NCBI Aggregate (95 GB) three formats: native, BLAST and WUBLAST –GenBank (206 GB) –GenPept (3 GB) –PDB (6.3 GB) –Prints (72 MB) –RepBase (8.6 MB) –UniProt (12 GB) –PFam (8.7 GB) –ProSite (16 MB) –TransFac (36 MB) Database update mechanism –follows the schedule of the distribution source –currently NCBI Aggregate is the only one updated nightly

Leveraging the TeraGrid BioScience and Biomedical Gateway Adapt the portal to use TeraGrid Resources –Support the Community Account usage model –Enhanced logging and tracking –New Distributed Administration features –Resource Site prep: Pre-Reqs, App deployment, etc Further decoupling of the web application tier and back-end computing tier

Future Directions Comprehensive BioScience Discovery and Learning Environment Hosting environment for RENCI production and research software Outreach and training