Osteoarthritis in the third millenium ; a new era for an old disease. Semin. Arthritis Reum. 2005.

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Presentation transcript:

Osteoarthritis in the third millenium ; a new era for an old disease. Semin. Arthritis Reum. 2005

Osteoarthritis

Heat shock proteins and their roles in chondrocyte protection,an aplication for autologous transplantation. Sawaatzky D A et al. Immunopharmacolo- gy.2005 Safety study of intrarticular injection of interleukin 1 receptor antagonist in patients with painful knee osteoarthritis: a multicenter study.Chevalier X. et. al. J. Reumatol.2005 The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13,cathepsine k and aggrecanases. Arthritis Research Therapy.2005 Sinovial tissue inflammation in early and late osteoarthritis.Benito M. J.et. al. Ann. Rheum. Dis.2005

PROTEOMICS Proteomics in Rheumatology, a new direction for old diseases. Ali M. et.al. Semin. Arthritits Rheum Proteomics characterization of human normal articular chondrocytes, a novel tool for the study of osteoarthritis and other rheumatic diseases. Ruiz-Romero C. et.al. Proteomics 2005

Gene Therapy Osteoarthritis gene therapy. C.H.Evans et.al.Gen. Ther Gene transfer to the human joint,progress toward a gene therapy of arthritis.C.H.Evans Proc.Natl.Acad.Sci Novel biological approaches to the intra-articular treatment of osteoarthritis.C.H.Evans.BioDrugs.2005.Gene therapeutics approaches –transfer in vivo.C.H.Evans.Adv.Drug.Deliv.Rev.May.2006

The burden of this disease will increase in direct proportion to the increase of the older population….. The major barriers to progress are financial rather than intellectual or technical.