Sydnone Chemistry and Microwave Assisted Synthesis of Sydnonyl-Substituted Imidazoles (I) Mei-Hsiu Shih Department of Chemical and Material Engineering.

Slides:

Advertisements

Similar presentations

Biological and Bioorganic Chemistry. Some useful material niichem.univer.kharkov.ua/physorg chemlaba.wordpress.com.

Advertisements

A Green Approach to Nitrogen Heterocycles: Application to Biologically Active Compounds Name: Josephine Dimbleby Department: Chemistry Supervisor: Andy.

Heterocyclic Chemistry

Heterocyclic Compounds

Chemical and biological studies on some Heterocyclic nitrogen derivatives.

Second Semester Organic Chemistry Options: Bioorganic or Organic Mechanism and Synthesis Albert Matlin and Jason Belitsky Department of Chemistry and Biochemistry.

Heterocyclic Chemistry

Heterocyclic Chemistry

Introduction. Definition Organic Chemistry is the chemistry of the compounds of carbon.

1 Amides and Amines: Organic Nitrogen Compounds Chapter 25 Hein * Best * Pattison * Arena Colleen Kelley Chemistry Department Pima Community College ©

Ingólfur Magnússon 12. May 2014

Merocyanine dyes Synthesis, properties, application

Click chemistry for synthesis of chitosan nanocarriers and biomaterials Ingólfur Magnússon 17th. June 2014.

Heterocyclic Compounds

Chapter 18 Carboxylic Acids and Their Derivatives

Studies on the Syntheses of Heterocycles from 3-Arylsydnone-4- carbohydroximic Acid Chlorides with N-Arylmaleimides, [1,4]Naphthoquinone and Aromatic Amines.

Microwave-assisted Thio-Pinner Reaction Scope and Limitation Loic Tessier and Jean Jacques Vanden Eynde * University of Mons – UMONS, Laboratory of organic.

ANTIULCER AGENTS Patrick An Introduction to Medicinal Chemistry 3/e

Dihydric alcohols Glycols. Dihydric alcohols (Glycols) They are saturated hydrocarbons in which 2 hydrogen atoms are replaced by 2(OH) groups. They are.

Chapter 18 Carboxylic Acids and Their Derivatives. Nucleophilic Addition-Elimination at the Acyl Carbon.

Ring Transformation of Heterocycles Adel M. Awadallah Chemistry Department, Faculty of Science, Islamic University of Gaza, P. O. Box108, Gaza, Palestine;

Organic Compounds Lab Name Date Period Grade. I. State the Problem: (Always ends in a question mark)

Science career project research Aurelio Alexis Espinoza Garcia.

Cyclic and heterocyclic aromatic compounds

Microwave assisted synthesis of sydnonyl- substituted imidazoles.

Option D: Medicines and Drugs Unit D.3.3: Structural Comparisons of Analgesics Chemistry SL Dixon Adair.

Adapted Zard Synthesis of Trifluoromethyl Ketones from Carboxylic Acids Brandon Mercer Department of Chemistry, University of New Hampshire, Durham, New.

WHAT IS A BIOCHEMICAL ENGINEER? Engineering I Fall 2014.

Carboxylic acids and their derivatives. Required background: Aldehydes, ketones Acidity of alcohols Reaction mechanisms Essential for: Aminoacids, peptides.

Ring Transformation of Heterocycles Adel M. Awadallah Chemistry Department, Faculty of Science, Islamic University of Gaza, P. O. Box108, Gaza, Palestine;

Synthesis of Garner’s Aldehyde Carmen Cannon, Kristina Truitt, Rachel Andrews, Bette’ Ford and Victoria Geisler Department of Chemistry, University of.

Chem 341 Review for Finals Structure Determination NMR –Chemical shifts, splitting patterns, integrations IR –ROH, C=O Formula => # of Rings + Pi-Bonds.

INTRODUCTION ~ PART 1 ~ Biomolecules. Chemistry of Life 1. Life requires about ____________naturally occurring chemical elements. A. _____________________________,

Introduction b-Dicarbonyl compounds have two carbonyl groups separated by a carbon Protons on the a-carbon of b-dicarbonyl compounds are acidic (pKa =

Solution Preparation and Dilutions. Solution Preparation How do we create chemical solutions in a laboratory setting with a certain concentration/molarity?

Modeling N–H ･･･ O Hydrogen Bonding in Biological Tyrosinate-bound Iron Centers INTRODUCTION Future Work: Table 1. Synthesis of 1 (2-Aminophenol). Finish.

Introduction to Natural Products Chemistry Cells of organisms - plants, fungi, bacteria, lichens, insects, animals - produce a large variety of organic.

APPLICATIONS Microwave heating is able to heat the target compounds without heating the entire furnace or oil bath This saves time and energy. However,

Pharmaceutical Organic Chemistry

Pharmaceutical Organic Chemistry By Dr. Mehnaz Kamal Assistant Professor Pharmaceutical Chemistry Prince Sattam Bin Abdulaziz University.

1 Chapter 25 Lecture Outline ntroduction 3 2. Structure and Bonding.

Medicinal Chemistry Lecture – I Introduction and Course Overview Joseph O. Oweta B. Pharm (MUST)

6 th J-NOST CONFERENCE DATE: VENUE: DST Auditorium UNIVERSITY OF HYDERABAD DATE: VENUE: DST Auditorium UNIVERSITY OF HYDERABAD DISCOVERY.

Structures and pKa values for acetic acid and benzoic acid

of novel 1,2,3-triazolyl appended L-ascorbic acid derivatives

Chapter 17 Carboxylic Acids and Their Derivatives Nucleophilic

Results and Discussion

International Arab Baccalaureate

DRUG DISCOVERY: FINDING A LEAD

GOVERNMENT ENGINEERING COLLEGE,BHARUCH-014

CH3204 Organic Chemistry Laboratory

Guideline prepared by the Veterinary Harmonisation Group

New Multi-redox Htereocycles for Materials Applications

Porphyrin Arrays as Light Harvesting Compounds Formed from Porphyrin Modules and Metal Linkers Alison Hyslop, Department of Chemistry, St. John’s University,

Porphyrin Arrays as Light Harvesting Compounds Formed from Porphyrin Modules and Metal Linkers Alison Hyslop, Department of Chemistry, St. John’s University,

Chapter 18 Carboxylic Acids and Their Derivatives

New Chiral Solid Catalysts for Oxidation Reactions

Design and Synthesis of Chiral Nematic Liquid Crystal Twist Agents

• First practical method for asymmetric hydrocyantion of a 1,3-diene

SEPTEMBER 11-15, 2019 Skopje, Macedonia

Disciplines and Sub-Discplines

Synthesis and Study of Triazenes and 2-Iminoimidazolines

New Multi-redox Htereocycles for Materials Applications

February 2007 Note: Source:.

Aldehydes and Ketones— Nucleophilic Addition

Asymmetric Synthesis Dr. S. Mangalaraj Assistant Professor

Yields from Varying Lab Sections Summary and Conclusions

Porphyrin Arrays as Light Harvesting Compounds Formed from Porphyrin Modules and Metal Linkers Alison Hyslop, Department of Chemistry, St. John’s University,

Presentation transcript:

Sydnone Chemistry and Microwave Assisted Synthesis of Sydnonyl-Substituted Imidazoles (I) Mei-Hsiu Shih Department of Chemical and Material Engineering Southern Taiwan University of Technology

Outline ( Ⅰ ) Introduction of sydnone chemistry ( Ⅱ ) Sydnonyl-substituted pyrazolines ( Ⅲ ) Thiadiazoline and thiadiazole derivatives ( Ⅳ ) Microwave assisted synthesis of sydnonyl- substituted imidazoles

( Ⅰ ) Introduction of sydnones (A) Background Sydnone was first discovered by Earl and Mackney in They obtained a five-membered cyclic compound by the action of acetic anhydride on N-nitro-N-phenylglycine. Electronic structure and varied types of biological activity.

(B) General synthetic procedure Sydnones were generally prepared by the action of certain dehydrating agents, notably acetic anhydride, on the N-nitroso derivatives of N-substituted α–amino acids.

(C) Physical and chemical properities Tetrahedron, 2002, December, 58, Tetrahedron, 2003, June, 59, Bioorganic & Medicinal Chemistry, 2004, September, 12, Synthesis, 2004, December, 17, (D) Biological activity (E) Syntheses of 4-heterocyclic substituted sydnones