Parasitic protists of human importance : Disease : Malaria Agent : Plasmodium 4 species Differential pathogenicity Vector-borne Apicomplexan inhabiting.

Slides:

Advertisements

Similar presentations

MALARIA causative agent = Plasmodium species

Advertisements

Anti-Malaria Chemotherapy

MALARIA 40% of the world’s population lives in endemic areas

CHAPTER 27 Animal-Transmitted, Arthropod- Transmitted, and Soilborne Microbial Diseases.

Malaria. Malaria is caused by a parasite called Plasmodium, which is transmitted via the bites of infected mosquitoes. In the human body, the parasites.

Up date on malaria vaccine

Malaria. Background Definition of malaria Malaria is an infectious disease caused by protozoan organisms of the genus Plasmodium (falciparum, ovale, vivax,

Name means “bad air”- A life-threatening parasitic disease 40% of the world’s population is at risk 90% of the deaths due to Malaria occur in Sub- Sahara.

MALARIA History The disease How people get Malaria ( transmission) Symptoms and Diagnosis Treatment Preventive measures Where malaria occurs in the world.

Eradication of Malaria So why did the campaign fail? 1) Insecticides (DDT) –Environmental damage!

Malaria Dept. of Infectious Disease Shengjing Hospital CMU.

Malaria Parasites Dr. Gamal Allam.

Mmmmm Mohamed M. B. Alnoor CHP400 COMMUNITY HEALTH PROGRAM-II mmmmm Malaria Epidemiology & Control.

Malaria By Sir David Ochieng March 15,

بسم الله الرحمن الرحیم انگلهای مالاریا.  Phylum: Apicomplexa  Class: Sporozoea  Sub-class: Coccidia  Order: Eucoccidia  Sub-order: Haemosporina 

Dr Aslesh OP MBBS, MD Assistant professor, community medicine Pariyaram Medical College.

MALARIA An infection.

COCCIDA – Malaria lecture NO-10-

The Protozoa Class Sporozoa - Malaria Four species of malaria parasites infect humans, Plasmodium vivax, P. ovale, P. malariae, and P. falciparum. All.

Parasitic protozoa of human importance : Disease : Malaria Agent : Plasmodium 4 species Differential pathogenicity Vector-borne Apicomplexan inhabiting.

By Chris Lew.  Malaria- “mal” (bad) “aria” (air)  Symptoms first described by Hippocrates in 400 B.C.E.  Ronald Ross receives Nobel Prize (1902) for.

Malaria Prof. Ahmed A Adeel Malaria Species Four species of malaria : – Plasmodium falciparum: malignant tertian malaria – Plasmodium vivax: benign.

MALARIA. INTRODUCTION CAUSES 1-3 MILLION DEATHS A YEAR ( MAINLY CHILDREN ). IT REMAINS A MAJOR BURDEN IN TROPICAL COUNTRIES. MALARIA MEANS MAL AIR NEAR.

Malaria parasite (plasmodium)

Malarial parasite Dr Zahra Rashid Khan Assistant Professor, Hematology

Plasmodium ( 疟原虫 ). History  Malaria is an old infectious disease. The first documentation about it is at 1500BC.  Until the end of the 19th century,

David P. Humber School of Biosciences University of East London

Malaria Jessy Cockrell.

Plasmodium (Malarial Parasite) Object – To study morphological structures of Plasmodia, to identify morphological structures of developing stages of erythrocytic.

Clinical features (fever) Cold stage: rigor (cold and shivers)

Malaria An Overview of Life-cycle, Morphology and Clinical Picture.

“Ensuring quality and access for malaria diagnosis: how can it be achieved?” Nat Rev Microbiol Sep;4(9 Suppl):S7-20. Amy Storfa 3/23/2007.

Genus: Malaria parasites. The malaria parasites are protozoan parasites, belong to the family plasmodium, and classified into many species. The plasmodium.

Malaria Dept. Infectious Disease 2nd Affiliated Hospital CMU.

Malaria By Mr. Shannon. Malaria: Symptoms Typical symptoms of malaria include fever, chills, vomiting, and anemia. Severe cases of malaria can occur quickly.

Dr Zahra Rashid Khan, Assistant Professor, Hematology Department of Pathology.

MALARIA. A vector-borne infectious disease Caused by protozoan parasites of the genus Plasmodium Plasmodium falciparum and Plasmodium vivax P.ovale, P.malariae.

Malaria Diagnosis, Treatment, Prevention. Welcome to Malaria World.

Malaria pan-R Malaria cassette. Agenda Disease overview Infectious agents Diagnosis pan-R Malaria cassette: specifications Conclusion.

Malaria An Overview of Life-cycle, Morphology and Clinical Picture.

Malaria (มาลาเรีย) Local names: ไข้จับสั่น ไข้ ป่า ไข้ป้าง ไข้ร้อนเย็น ไข้ ดอกสัก Pathophysiology, diagnosis, epidemiology and control 1.

Malaria (มาลาเรีย) Assoc. Prof. Pradya Somboon, Ph.D. 1.

Malaria An Overview of Life-cycle, Morphology and Clinical Picture.

Malaria Lecure-9- Hazem.K. Al-Khafaji. Topics: Definition. Epidemiology Etiology. Pathology. Clinical features. Complications. Diagnosis. Treatment. Prevention.

MALARIA ALE LIZ /GLORIA BIOLOGY. P ATHOGEN Malaria is caused by single-celled organisms, called protozoans, of the genus Plasmodium. Different forms of.

Global Health Malaria. Transmission Malaria is spread by mosquitoes carrying parasites of the Plasmodium type. Four species of Plasmodium are responsible.

Lecture 27,28,29,30: Parasitology 4 lectures titled L 27: Intestinal protozoa L 28: Blood and tissue protozoa L 29: Intestinal helminths 4 lectures titled.

MALARIA. Over view  Basic understanding of malaria  Epidemiology  Symptoms  Diagnosis  Treatment  Prevention.

Class sporozoa Genus Plasmodium

MALARIA Seema Jain, MS4 6/9/16. BIOLOGY Female Anopheles mosquito is infected with malaria parasites. The mosquito acts as a vector, carrying disease.

CATEGORY: PATHOGENS & DISEASE

Malaria Amal Hassan.

Malaria: Plasmodium sp.

Malaria An Overview of Life-cycle, Morphology and Clinical Picture.

PRACTICAL ON BLOOD PARASITES

BY DR WAQAR MBBS, MRCP ASST PROFESSOR

Epidemiology & control of tropical disease

ARULANANDAM TERENCE.T 403(A)

Malaria An Overview of Life-cycle, Morphology and Clinical Picture.

Plasmodium Life Cycle Mark F. Wiser

Apicomplexa: Plasmodium

Malarial life cycle… Dr.Shelke A.N. Assist.professor

EPIDEMIOLOGY OF MALARIA BY MBBSPPT.COM

Pathogenic Protozoa.

Malaria Dr MONA BADR An Overview of Life-cycle, Morphology and

Presentation transcript:

Parasitic protists of human importance : Disease : Malaria Agent : Plasmodium 4 species Differential pathogenicity Vector-borne Apicomplexan inhabiting liver & blood

Global malaria mortality between 1980 and 2010: a systematic analysis Murray et. al Lancet vol 379, February Key findings: Mortality burden higher in adults than previously estimated. Significant decline in mortality in Africa.

Malaria Plasmodium vivax : Most predominant and only species which extends to temperate regions. Benign tertian. Relapses. Plasmodium ovale : Tropical Africa, occasionally S. America and Asia. Ovale tertian. Relapses Plasmodium malariae : Primarily subtropical. Less frequent. Quartan.

Malaria Plasmodium falciparum : Most pathogenic species. Entirely confined to tropics and subtropics. Clinically sharply differentiated from the other three species. Malignant tertian.

Malaria : diagnosis Microscopy : Blood smears : thin versus thick smears Differentiation from P. falciparum (medical emergency in non-immune) Rapid diagnostic antigen test Serology Gene amplification methods

Plasmodium vivax

Plasmodium ovale

Plasmodium malariae

Complications Cerebral malaria Anemia Renal disease Blackwater fever Dysenteric malaria Algid malaria Hyper-reactive malarial splenomegaly (HMS)

Malaria and pregnancy

Pathogenesis Sequestration + cytoadherence : stage & strain- specific parasite- derived ligands Host secreted proteins : cytokines : TNF and interleukins Differential ability to infect RBCs RBC recognition and invasion Paroxysm

Epidemiology Transmission : characteristics of the vector Other forms of transmission (blood transfusion, shared needles, congenital) Innate resistance : red blood cell defects Immunity Control : eradication versus containment

Treatment : malaria Management of severe falciparum malaria Chloroquine-resistant P. falciparum Chloroquine-sensitive P. falciparum or P. vivax, P. ovale and P. malariae Severe falciparum chemotherapy Chemotherapy for P. vivax and P. ovale Chemotherapy for P. malariae

Prevention and Control Malaria control strategy Early diagnosis & treatment Selective & sustainable prevention against parasite & vector To detect & contain epidemics To reassess regularly a country’s malaria situation Roll back malaria campaign/WHO strategy –Note : impregnated bednets

First results of Phase 3 Trial of RTS,S/AS01 malaria vaccine in African children The RTS,S Clinical Trials Partnership New England Journal of Medicine, November 17, 2011 vol 365, no. 20 Current leading recombinant pre-erythrocytic malaria vaccine candidate: RTS,S/AS01or AS02 (circumsporozoite protein)