LIQUID DOSAGE FORMS PART II

PREPARATION OF MIXTURES

Rule preparation of mixtures: At preparation of dosage forms hold to the set procedure of dissolution and mixing of medications taking into account their physical and chemical properties. At preparation of dosage forms hold to the set procedure of dissolution and mixing of medications taking into account their physical and chemical properties. Always at first measure a distilled water. In the bottle in distilled water dissolve solid substances in a next sequence – at first narcotic, poisonous, strong affective, then general list. (at first – heavily soluble, and then – easily soluble), If sum of solid substances more than 3 % take into account the coefficient of increase of volume. Always at first measure a distilled water. In the bottle in distilled water dissolve solid substances in a next sequence – at first narcotic, poisonous, strong affective, then general list. (at first – heavily soluble, and then – easily soluble), If sum of solid substances more than 3 % take into account the coefficient of increase of volume.

Percolation in a small bottle through the double layers of gauze, or tampon Percolation in a small bottle through the double layers of gauze, or tampon Add the concentrated solutions from the burette system, at first narcotics, after that general list in order according to the prescription Add the concentrated solutions from the burette system, at first narcotics, after that general list in order according to the prescription Add not fragrant and non-flying liquids ( syrups, tinctures); then alcoholic liquids, in the order of growth of concentration of alcohol; are fragrant and volatile liquids Add not fragrant and non-flying liquids ( syrups, tinctures); then alcoholic liquids, in the order of growth of concentration of alcohol; are fragrant and volatile liquids

Rp: Analgіnі 3,0 Kalіі bromіdі 4,0 Aquae purіfіcatae 200ml Tіncturae Beladonnae 8ml Tіncturae Valerіanae 10ml Mіsсe. Da. Rp: Analgіnі 3,0 Kalіі bromіdі 4,0 Aquae purіfіcatae 200ml Tіncturae Beladonnae 8ml Tіncturae Valerіanae 10ml Mіsсe. Da. Sіgna. 1 soup-spoon 3 times a day Sіgna. 1 soup-spoon 3 times a day

WCP (reverse side): Total volume: 200ml+10ml+8ml=218ml. Concentrated solution Kalіі bromіdі 20% (1:5) 4,0  5=20ml. Analgіnі 3,0 218 ml – 3,0 100 ml – Х Х = 1,7% (1,7%  3%) Aquae purіfіcatae = 180 ml

WCP (front side): Date prescription № Aquae purіfіcatae 180ml Aquae purіfіcatae 180ml Analgіnі 3,0 Analgіnі 3,0 Solutіonіs Kalіі bromіdі (1:5) 20ml Solutіonіs Kalіі bromіdі (1:5) 20ml Tіncturae Beladonnae 8ml Tіncturae Beladonnae 8ml Tіncturae Valerіanae 10ml Tіncturae Valerіanae 10ml V total = 218 ml V total = 218 ml Has prepared: Has prepared: Has checked up: Has checked up:

In porcelain cup measure off 180ml of the cleared water and dissolve a 3,0 analgin. Solution percolate through a piece of wool in a small bottle for dispense. There measure off 20 ml of solution potassium bromide (1:5), then tincture of Belladonna, in the last turn measure off the tincture of valerian (prepared on a 70% alcohol). Will glue on the number of recipe, label "Mixture",, "before the use to shake" up. In porcelain cup measure off 180ml of the cleared water and dissolve a 3,0 analgin. Solution percolate through a piece of wool in a small bottle for dispense. There measure off 20 ml of solution potassium bromide (1:5), then tincture of Belladonna, in the last turn measure off the tincture of valerian (prepared on a 70% alcohol). Will glue on the number of recipe, label "Mixture",, "before the use to shake" up.

Rp: Kalіі іodіdі Natrіі bromіdі aa 5,0 Natrіі bromіdі aa 5,0 Glucosі 15,0 Glucosі 15,0 Aquae purіfіcatae 180ml Aquae purіfіcatae 180ml Mіsсe. Da. Sіgna. 1 tablespoon 3 times a day. Mіsсe. Da. Sіgna. 1 tablespoon 3 times a day. At first determine the percentage of the total glucose mixture. 180 ml ml – X X = 8,3%, more than 3%.

15.0  0,69=10,35(ml), is much more tolerance than in 3,6 ml. In this case calculation of amount of water for recipe conduct by such method : the concentrated solution- sodiums bromide 20% (1:5) and potassium bromide 20% (1:5) it is necessary to take for 25ml (5,0  5=25); water: 180ml-(25ml+25ml+10,35ml)=119,6ml Technology of preparation following: in porcelain cup measure off 120ml of water (better warm) and dissolve a 15.0 glucose, percolate solution in a small bottle for dispense; there measure off for 25ml 20% solution of potassium iodide and 20% concentrated solution-sodium bromide. Labels are "Mixture", to "Keep in a cool place", number of recipe.

WPC Date № prescription Date № prescription Aquae purіfіcatae 120ml Aquae purіfіcatae 120ml Glucosі 15,0 Solutіonіs Kalіі іodіdі (1:5) 25ml Solutіonіs Kalіі іodіdі (1:5) 25ml Solutіonіs Natrіі bromіdі (1:5) 25ml Solutіonіs Natrіі bromіdі (1:5) 25ml V total =180ml V total =180ml Prepared: Checked: Prepared: Checked:

Rp: Kalіі bromіdі Natrіі bromіdі aa 2,0 Natrіі bromіdі aa 2,0 Aquae Menthae ad 200ml Aquae Menthae ad 200ml Mіsсe. Da. Sіgna. По 1 столовій ложці 3 рази в день. Mіsсe. Da. Sіgna. По 1 столовій ложці 3 рази в день. In the case, when of the recipe as a solvent prescribed flavored water is allowed to use concentrated solutions of powdery substances and Capacity factor of increased do not use. In the case, when of the recipe as a solvent prescribed flavored water is allowed to use concentrated solutions of powdery substances and Capacity factor of increased do not use. Technology: measure off 200ml of water mint and dissolve in it 2.0 sodium bromide and potassium bromide, and then filtered in the bottle for dispensing. Technology: measure off 200ml of water mint and dissolve in it 2.0 sodium bromide and potassium bromide, and then filtered in the bottle for dispensing. WPC WPC Date № prescription Date № prescription Aquae Menthae 200ml Aquae Menthae 200ml Kalіі bromіdі 2,0 Kalіі bromіdі 2,0 Natrіі bromіdі 2,0 Natrіі bromіdі 2,0 V tot. = 200ml V tot. = 200ml Prepared: Prepared: Checked: Checked: