Nuclear Medicine division status Jean-Michel Poutissou 7 th April 2011

Response to last year’s report Formal screening of new projects MHESA project status CCM status Expansion of wet laboratory space New recruitment Graduate students Solid target New imaging detectors MDS Nordion collaboration

November 29 th retreat 15 months NRCan NISP grant for cyclotron production of 99m Tc received : Tight delivery deadlines. (March 2012) NSERC/CIHR grant ongoing (LS96) linked to the above. MHESA new radiochemistry laboratory ( Joint project with Nordion) finally on track to be done soon ( TRIUMF`s share in the NRC budget to be expended by March 2011) GMP lab to be operational in December Radiochemistry research projects

NUMED FY Goals 1) deliver on the NRCan project milestones 2) Deliver Tracers to our best partners like PPRC,PET centre, BCCA, UBC faculties,Nordion, GE,.. We need: MHESA laboratory completion and operation GMP lab Operation

Other goals Centre Comparative Medicine – New MicroPet /Spec scanner (CFI-Vesna) – Design of new pipeline connection to CCM Detector development: – New MicroPet/MRI scanner F.Retiere CFI proposal ( U.Manitoba/UBC/TRIUMF) – New “low” cost PET scanner development ( TRIUMF/BCCA) by Fabrice Retiere

Other projects under consideration Second CDR grant with Nordion Grant application with Genome BC Canadian Molecular Imaging Network centre of excellence proposal to be submit by August

AJJOAJ 2010 JOAJ 2011 JOAJ 2012 AJO 2013 November 29, 2010 Major Tasks JAJO 2014 NU-MED Plan ( ) Tender & award contract Funding approved Target development and testing Team organized Detailled design Report to NRCan Install Cyclotron proposal Commissioning.New building/TR19 relocation GMP lab 005 operation MHES LAB Construction Animal GMP lab 005 Hot cells delivery GMP lab 007 upgrade ?? Icfi PROPOSAL (MULTI MODAL FACILITY) CFI proposal ( MPET/SPEct/ct piPELINE JMP mTc production Milestones NRU restart ommissioningl ) Legend: Research Infrastructure construction Science

Deputy Division Head New Programs P.Schaffer New Infrastructure (P&S) New Tracers Radiochemistry – Lead Scientist (BAE) Targets/Medical Isotope Production – Lead Scientist (BAE) SeniorTarget Scientist Target Engineer Target Chemist Electro- mechanical Engineer Cyclotron-Ops Nuclear Medicine J.M. Poutissou Deputy Division Head Core Programs M. Adam Special Advisor T. Ruth NRCan SeniorTarget Scientist Target Engineer Electro- mechanical Engineer Target Chemist Project ManagerNSERC/CIHR Principal Investigator NRCan Partners

NRCan NISP project

New infrastructure GMP laboratory RCA005 upgrade: – 3 new hot cells ( Comecer) – 3 new chemistry boxes – New ventilation strategy – Clean room environment

GMP lab/personnel

MHESA laboratory

Centre for Comparative Medicine Construction on going Occupancy ( early 2012) CFI proposal for a Spect/Pet micro scanner by V.Sossi and P.Schaffer. Major concern with PETA activist group New policy on disclosure of our LSPEC proposals and reports

Hiring plan One extra Scientist ( radiochemist) One professional ( MHESA lab manager) Mike Adam will be replaced when he retires. Several additions to the target group will be absorbed when the NRCan project terminates ( new soft funding or NRC bridge funding)

Students/ Postdocs NRCan NISP project: TOM MORLEY, PDF PPRC/UBC PET Centre collaboration and the Good Manufacturing Practice Laboratory (GMP) upgrade: G. TOPPING, PHD STUDENT (LS 94) 1 MSc STUDENT (VESNA) 3 PHD STUDENTS ( VESNA) NORDION/TRIUMF collaboration: ESTER BOROS, PHD STUDENT ERIC PRICE, PHD STUDENT CATERINA RAMOGIDA, PHD STUDENT JAQUELINE CAWTHRAY, PDF LISA MURPHY, PDF

Students/Postdocs BCCA-TRIUMF collaboration: NONE AT THIS TIME GE Healthcare Collaboration: HUA YANG, PDF CIHR/GENOME BC proposal (OLIGONUCLEOTIDES, MICRO-FLUIDICS): JAMES INKSTER, PHD STUDENT KATE LIU, CO-OP STUDENT SAMAR HAROUN, PHD STUDENT ZARA SANAI, PHD STUDENT YING LI, PHD STUDENT M. POURSHIASIAN, PHD STUDENT Collaboration with UBC’s Centre for Comparative Medicine (CCM): TBA MINet collaboration: TBA

Policy for the SAP-EEC,MMS-EEC and LSPEC In order to align TRIUMF policies on openness with other laboratories around the world, this document outlines in broad terms our new policies. Below EEC refers to all three committees. 1) All proposals submitted to TRIUMF will be available for view on the TRIUMF internal WEB in their entirety after review and if approved by the EEC. – a. Only the title, author list, status, and short abstract (< 300 words) will be displayed on the public web pages. – b. The EEC reports (and comments) are internal TRIUMF documents and will only be displayed on the internal TRIUMF web site. The full EEC report will be made available to the appropriate external funding committees. – c. Proposals with private sector partners should follow Non Disclosure Agreements.(NDA) 2) Presentations to the EECs are open to everyone. Slides are available to the committee only. 3) Review committee members will treat the content of proposals as confidential. 4) Requests for information on proposals from outside the TRIUMF community will be granted only by the authors in consultation with TRIUMF communications. 5) Within 60 days of receiving beam time the spokesperson will provide to the Science Division for posting, on the public WEB pages, a short summary (< 300 words) of the experiment results. The summary of results will be used in the annual report. Details are disclosed at the discretion of the spokesperson. 6) The interpretation and application of this policy is the responsibility of the respective Division Head.