Macromolecular Crystallography Summary of the July 18, 2007 Breakout Session.

Slides:

Advertisements

Similar presentations

Layered EPICS User Gap Control Interface for NSLS Mini-gap Undulators William Nolan and John Skinner, Biology Department Susila Ramamoorthy and Lonny Berman,

Advertisements

RYERSON UNIVERSITY 1 3. SETTING UP A LAB. RYERSON UNIVERSITY 2 Biological Safety Training – Certificate Holder and User Training 3. SETTING UP A LAB Topics.

NSLS-II Stability Workshop – User Requirements Working Group – Day 1 Stability Requirements for soft x-ray coherent microscopy/imaging -- C. Jacobsen :

User requirements Session chair K.Evans-Lutterodt Speakers: Jorg Maser N. Simos D.Arena P.Northrup C. Sanchez-Hanke.

Stanford Synchrotron Radiation Lightsource Sources and Optics for XAS Apurva Mehta.

NSLS-II Life Science Breakout Session. Agenda  Introduction (Miller)  Keynote Speaker: Carolyn Larabell (ALS, UCSF) (30 min)  Technique talks (4 min.

1 BROOKHAVEN SCIENCE ASSOCIATES National Synchrotron Light Source II Damping Wiggler Beamline: XAS Preliminary Design Summary Paul Northrup January 16th,

1 BROOKHAVEN SCIENCE ASSOCIATES National Synchrotron Light Source II New Science Nanoscience Life Science Nanocatalysis New Capabilities Nanoprobes Diffraction.

Structural Genomics – an example of transdisciplinary research at Stanford Goal of structural and functional genomics is to determine and analyze all possible.

Future directions in research on biomolecular structure NSLS-II Workshop July 17,2007.

University of California Academic Business Officer Group Conference 2012 Fess Parker DoubleTree Resort by Hilton Santa Barbara April 15 th -17 th “Navigating.

John Arthur X-Ray Optics October 12, 2004 X-Ray Prototype Optics Specifications John Arthur.

LIGO-G W LIGO Hanford Observatory Infrastructure Frederick J. Raab, LIGO Hanford Observatory.

Collecting Macromolecular Crystallographic Data at Synchrotrons Andrew Howard ACA Summer School 12 July 2007.

Collecting Macromolecular Crystallographic Data at Synchrotrons Andrew Howard ACA Summer School 21 July 2005.

Epics Collaboration Meeting Pohang Oct 2012

Synchrotron Powder Diffraction Simplified: Introducing the Advanced Photon Source’s dedicated high-resolution beamline 11-BM Matthew Suchomel, Brian Toby,

Environmental Sciences Department BNL Environmental Sciences Dept. and EnviroSuite: from NSLS to NSLS-II Jeff Fitts July 18, 2007 Environmental Research.

1 BROOKHAVEN SCIENCE ASSOCIATES Lonny Berman and Dario Arena, NSLS Summary The present built-out NSLS-II design includes: 30 bending magnet ports, each.

What Is a Synchrotron? From the BNL Website Introduction The human eye can see only visible light. It comes in the form of different wavelengths. These.

Materials Science and Protein Crystallography Using the MX Beamline Control Toolkit William M. Lavender

Lars Ehm National Synchrotron Light Source

1 BROOKHAVEN SCIENCE ASSOCIATES Experimental Facilities John Hill CFAC review October 18 th, 2006.

The Development of Laue Monochromator at X17B3 National Synchrotron Light Source in (111) diffraction intensities by severer of non-bending Si.

Kappa Group Meeting - September BL13 — XALOC Guifré Cuní Jordi Juanhuix on behalf of the XALOC team.

Where do the X-rays come from?. Electric charge balloon Wool Sweater

“hands-off” Screening with TOPAZ Chips For the purposes of testing both crystallization behavior and capability of the “tray goniometer”, chips were built.

Stability Requirements for Superconducting Wiggler Beamlines

7/23/99 NIH/NIGMS Support of Structural Biology NIH individual research grants with crystallography projects (FY 98) –primary: 225 grants, $51M total costs.

Commissioning of the CMCF 08ID-1 Beamline. Light in the Optical Hutch September 2005 Light at the entrance to the white beam slits (42 m). The rectangular.

1 BROOKHAVEN SCIENCE ASSOCIATES NSLS-II Overview Satoshi Ozaki Director, Accelerator Systems Division NSLS-II Project March 27, 2007.

ELECTRON MOVING AT CONSTANT VELOCITY

NSLS X-Ray High Pressure Research Workshop (February , 2006 ) Strategic Plan for XR-DAC at the NSLS.

IFS prototype – PM3 LAM, 13/06/2003 Prototype testing at CRAL Tests at room temperature in the visible.

1 BROOKHAVEN SCIENCE ASSOCIATES NSLS-II Strategic Planning John Hill Experimental Facilities Division Director NSLS-II EFAC May 5 th 2008.

X-17 DAC Operations at NSLS Progress Report June 2007 Jiuhua Chen.

Plans for the DAC Program at X-17 Short term (existing $90K) Purchase symmetric DACs and diamonds Install Laue-Laue mono in 17B3 (NSLS provides) Improve.

Computing at SSRL: Experimental User Support Timothy M. McPhillips Stanford Synchrotron Radiation Laboratory.

Feb 18 & 19, 2009 © Thayumanasamy Somasundaram 1 X-Ray Facility Overview IMB X-Ray Facility (IMB XRF) Kasha Laboratory

1 BROOKHAVEN SCIENCE ASSOCIATES A Wiggler Beamline for XAS at NSLS-II Paul Northrup NSLS-II Project and Environmental Sciences Department Brookhaven National.

BROOKHAVEN SCIENCE ASSOCIATES NSLS-II - New opportunities for high pressure research - Lars Ehm National Synchrotron Light Source Brookhaven National Laboratory.

Elke Zimoch, EPICS Workshop 2004 Japan EPICS at the Protein Crystallography Beamlines of the SLS.

Sébastien Boutet LUSI DOE Review July 23, 2007 CXI (WBS 1.3) 1 Coherent X-ray Imaging (WBS 1.3) Sébastien Boutet System Specifications.

1 BROOKHAVEN SCIENCE ASSOCIATES Powder Discussion Session Summary 1)What are the key scientific drivers? What experiments will NSLS-II enable that are.

Diamond update and kappa activities village structure 19 operational beamlines 5 operational MX beamlines one MX beamline (I23) under construction mini.

Motion Control at the Advanced Photon Source Argonne National Laboratory Mark Rivers University of Chicago 7 GeV synchrotron x-ray light source, the largest.

X-ray diffraction for today and tomorrow

NATIONAL SYNCHROTRON RADIATION CENTRE SOLARIS JAGIELLONIAN UNIVERSITY, KRAKOW, POLAND Piotr Goryl Tango Collaboration Meeting, Elettra,

ID11 beamline Multipurpose beamline for diffraction experiments

National SYNCHROTRON Radiation Centre SOLARIS Jagiellonian University, Krakow, Poland Piotr Goryl Motion Workshop, Soleil,

Biomolecular X-ray Crystallography Facility

MSc-Student Activities at the European XFEL

BigPanDA Technical Interchange Meeting July 20, 2017 Hong Ma

SSRL Beam Line Infrastructure Update February 2002

Mark Rivers University of Chicago

Electric Grid Technology Energy Storage Technology

Introduction to Synchrotron Radiation

X-ray Correlation Spectroscopy (WBS 1.4) Aymeric Robert

Davide De Salvador INFN-Laboratori Nazionali di Legnaro &

Graduate mentor: Renjie Zhou Faculty mentor: Lynford Goddard

Operation and Safety ART Review Harald Sinn.

Commonly used lab space

What would you do if you had one of the world’s most powerful x-ray sources in your backyard? Prof. Sol M. Gruner, Director Sol M. Gruner, Director.

X-Ray Facility Overview

mXRF and mXAFS with the GSECARS X-ray Microprobe

X-ray Pump-Probe Instrument

X-Ray Endstations Update

Optics John Arthur, SLAC & William W. Craig, LLNL April 24, 2002

Coherent X-ray Imaging Instrument WBS 1.3

Crystallography/melts Breakout Session, Afternoon, Feb 25 (Prepared by Guoyin Shen) Recommendations for X17 P-T generation and condition Probing beams.

Presentation transcript:

Macromolecular Crystallography Summary of the July 18, 2007 Breakout Session

Beam line (s) - current resources Most common beamline elements in use Optics Source: Undulators; Wigglers Monochromators: double crystal, sagital focusing, channel cut-Silicon Mirrors: focusing, collimating; Kirk-Baez pairs Energy range: KeV End-station Diffractometers:Build In-house or Crystallogic (single axis, kappa); Hubbert; EMBL MicroDiffractometer* Detectors: ADSC, MarCCD Control: Blu(Web)ICE Science Highlights Beamlines: X6A, X29 Technique: Macromolecular Crystallography Researchers: Yongcheng Wang, Yingjiu Zhang and Ya Ha (Yale School of Medicine) Publication: “Crystal structure of a rhomboid family intramembrane protease” Nature (2006) 444,

What can be done with a new source such as NSLSII Challenges  Molecular Machines - multiple stage molecular machines  Membrane Proteins  Virus  Structural “-omics”  Drug development (vaccines, anesthetics…) oTime resolved….kinetics….dynamics Very small less then 10 micron or most probably smaller crystals Weakly diffracting crystals 50 ang 250 ang 750 ang

My next Macromolecular Crystallography beam line(s) Beam lines Small beams, positional stability, small divergence, beam line automation. Optics Monochromator: Si 311 Mirror: KB mirrors (bimorph?) Energy range: 3(2) to 60 keV End-station Large detectors, continuous read out preferred Rotation axis with small sphere of confusion (< 1 micron) Crystal visualization/centering tools (need research) Ancillarydevices

Laboratories and ancillary facilities Labs Wet labs, cold rooms microscopes crystallization facilities (?) Biohazard Level (?) DI-water Mechanical, Electrical IT remote user access security e.g. through certificates large capacity data storage My next Macromolecular Crystallography beam line(s)

Facility meeting rooms small and medium or convertible offices for staff and visitors lunch room for users and staff Housing short stay - hotel like long stay - 1, 2, 3 Bedrooms with kitchen facilities Food vending automats - better setup then the vending machines small convenience store (18/7) Transportation campus only between BNL Stony Brook and Ronkonkoma train station (?)paid IT wireless network on campus Quality of Life