Neurological Disease Ontology Alexander Diehl University at Buffalo October 5, 2011.

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Presentation transcript:

Neurological Disease Ontology Alexander Diehl University at Buffalo October 5, 2011

Ontologies for Neuroscience and Neurology The Neurological Disease Ontology (ND) – Based on the Ontology for General Medical Sciences – Incorporates parts of NIF-Dysfunction and the Disease Ontology – Three initial areas of focus Dementia, in particular Alzheimers Multiple Sclerosis Stroke, Cerebralvascular events

Ontology Development Based on published existing ontologies as well as the scientific literature, including original articles, reviews, and text books Ontology terms (classes) are given both textual and logical definitions. Logical definitions relate the term to terms in other ontologies.

Ontology Development Top-Down and Bottom-Up Approaches Utilized. Top-Down starts with high level categories and fills in more specialized classes. Bottom-Up looks at specific literature and sees what classes are needed to represent a domain.

The Ontology for General Medical Sciences (OGMS)provides top level classes for the Neurology Disease Ontology.

Bottom-Up (Annotation-Driven) Ontology Development Lancet (1998) 352:1498

9 Bottom-Up (Annotation-Driven) Ontology Development Lancet (1998) 352:1498

Bottom-Up (Annotation-Driven) Ontology Development Journal of Neuroimmunology (2007) 188:167

Bottom-Up (Annotation-Driven) Ontology Development Journal of Neuroimmunology (2007) 188:167

Bottom-Up (Annotation-Driven) Ontology Development Nature Genetics (2010) 42(6):495

Bottom-Up (Annotation-Driven) Ontology Development Nature Genetics (2010) 42(6):495

A Proto-MS Ontology

Alexander Diehl Neurological Disease Ontology (MS, Dementia, Stroke) Mark Jensen, Alexander Cox, Bianca Weinstock-Guttman, Kinga Szigiti, Alan Ruttenberg, Barry Smith