The Urinary System Michael Hall University of California Los Angeles Mannekin Pis
Nephron Collecting Duct Uriniferous tubule
THE RENAL CORPUSCLE HAS: UPVPUS PE VE A simple squamous parietal epithelium (PE) which lines Bowmans capsule (BC). A tuft of capillaries called the glomerulus (G) A modified epithelium lining the capillaries (VE) A vascular pole (VP) A vascular pole (VP) A urinary pole (UP) A urinary space (US) G BC
Renal Corpuscle Efferent arteriole Afferent arteriole Filtrate Bowman’scapsule Bowman’s capsule Glomerulus Urinary space
Filtration apparatus of renal corpuscle Basal lamina Filtration slit membrane Fenestrated endothelium of capillary Podocyte Pedicel
Fenestrations Basal lamina Pedicels Filtration slit membrane RBC capillary
The glomerular basement membrane is a size and charge-selective barrier SIZE: Only proteins below 60,000 mw can get through the fenestrae and slits CHARGE: It is anionic (sialoproteins and proteoglycans) Most macromolecules are anionic at neutral pH, so they are repelled The glomerular basement membrane is a size and charge-selective barrier SIZE: Only proteins below 60,000 mw can get through the fenestrae and slits CHARGE: It is anionic (sialoproteins and proteoglycans) Most macromolecules are anionic at neutral pH, so they are repelled
Thin loop of Henle Ascending straight segment Distalconvolutedtubule Collecting duct Proximalconvolutedtubule Descendingstraightsegment Vasa recta
Collecting duct PCT DCT microvilli Tubules in cortex of kidney
CD Thin loops of Henle Tubules in medulla of kidney PCT DCT
Distal convoluted tubule Macula densa PCT DCT
Distal tubule JG cells The Juxtaglomerular Apparatus Glomerularcapillaries
ACE The role of the JG cells on the permeability of the collecting ducts to water Cells of macula densa sense decreased blood volume/flow from posterior pituitary
Changes in osmolarity in blood and urine during urine formation vasa recta
Manneken Pis has over 500 outfits that are used for special occasions
Blood vessels of the kidney
Renal Blood Supply
Arcuate artery and vein Cortex Medulla Renalcorpuscles
Interlobular arteries Lobule
Interlobular arteries
Juxtamedullary nephrons and vasa recta Cortical nephron Juxtamedullarynephron Loop of Henle Vasa recta
Renal papilla
Papilla Minor calyx
transitionalepitheliumUreter
Bladder
Bladder (relaxed) Bladder (stretched) Transitional epithelium
Urethra
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Blood circulation in kidney ILAfferentEfferent juxtamedullary nephrons