Innovation Acceleration Partner Fellows Program Approaches to Improving Commercialization and Innovation National Science Foundation Partner for Innovation Award ID: W ashington University in St. Louis and the University of Missouri-Columbia Presented to: Tiger/Kauffman Sponsored Workshop February 27, 2010 Ken Harrington Washington University in St. Louis Innovation Acceleration Partner Fellows Program Approaches to Improving Commercialization and Innovation National Science Foundation Partner for Innovation Award ID: W ashington University in St. Louis and the University of Missouri-Columbia Presented to: Tiger/Kauffman Sponsored Workshop February 27, 2010 Ken Harrington Washington University in St. Louis

Overview 1.Grant goals 2.Approach 3.First year outcomes 4.Issues for year two 5.Valley of Death

Grant Goals 1.Train fellows 2.Reduce roadblocks that discourage faculty 3.Find new innovation models 4.Move science from bench to the market 5.Enhance the culture

Targeted Roadblocks 1.Lack of time 2.Limited understanding of the commercialization process 3. Lack collaborative social network 4. Fear of publication delays

Approach 1.Focus on researchers 2.Work within the existing framework 3.Provide new support to researcher 4.Discuss possibilities openly 5.Consider “breakthrough” approaches

Involved Parties

Concept-Pre Disclosure Support

Outcomes-Two Innovation Models

Measurements

Wash U Basic Science Model

IAP Fellows  Amit Kumar  Ph.D. Molecular Biophysics  Justin Brown  Ph.D. Pharmacology  Kunal Rehani  Ph.D. Immunology

Overview of Wash U Technologies Triage I Criteria: Technology Licensing or start-up Stage of development Intellectual Property (IP) Triage II Criteria: Triage I Criteria AND… OTM approval Inventor enthusiasm Market analysis FDA regulatory process

Opportunity Evaluation Tool

Majority OTM Supplied 75 Opportunities

Five Opportunities Selected

Other Potential Opportunities

Mizzou BioDesign Model

BioDesign Fellows  Rebecca Rone  MS BioEngineering  Anthony Harris  MD/MBA  Jonathan Thompson Jr.  MD

Three Phases of Biodesign  Phase One (Physician) Clinical Emersion  Phase Two (Engineer) Product design  Phase Three (MBA) Business Development MD MBA ENG Critical Mass

Program Detail – Applied Research Needs & Solutions ProductProduct Business Plan

Tools: Needs Database

Rapid Indexing

First Year  15 Invention Disclosures 1/8 of all FY09 Columbia campus disclosures  2 Provisional Patents Filed  Prototype animal testing  Founding of Limited Liability Company SBIR application submitted Missouri LSRB commercialization letter of intent

MU Invention Disclosures  9 Minimally Invasive Devices  3 Real Time Patient Monitoring Devices  2 Minimally Invasive Cosmetic Devices  1 Laparoscopic Trainer

Innovation Model Constraints

Entrepreneurial expectancy Perceived need for new outcome Entrepreneurial self-efficacy Entrepreneurial intent Entrepreneurial desirability. Have idea for start-up Fellows’ Impact What Environmental Factors are the Multipliers Creating Entrepreneurial Intent?

Year 2 Issues Logic  # quality opportunities  # undisclosed opportunities  # concurrent projects Triage Types of technology Start-up Environment  Fellows’ skills  Duration of fellowship  Fellow funding  Proof of concept and prototype funding ($TBD)  Patent funding  Transaction costs & time

Valley of Death Proof of Concept Funding Lower Transaction Cost Faster Resource Access Entrepreneurial Partner Rapid Prototyping Invention Disclosure Rapid Prototyping Value Milestone Regulatory Process Faster Decisions

Key Questions? 1.Process improvement? 2.Structural change? 3.Amount of resources? 4.Sustainability? 5.Level of breakthrough

Contact Information Ken Harrington, Managing Director Skandalaris Center for Entrepreneurial Studies Washington University in St. Louis Campus Box 1133 One Brookings Drive St. Louis, Missouri